S0292

Silymarin

flavonolignans

• Synonyme(s) : flavolignans
• Numéro CAS: 65666-07-1
• Numéro MDL: MFCD01776359
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.81

Propriétés

• Source biologique: plant (Silybum marianum)
• Niveau de qualité: 200
• Forme: powder
• Technique(s): toxicology assay: suitable
• Application(s): microbiology
• Température de stockage: −20°C
• Chaîne SMILES: O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO
• InChI: 1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
• Clé InChI: SEBFKMXJBCUCAI-UHFFFAOYSA-N

Description

Description générale

Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

Application

Silymarin has been used to study:

• its in vitro antiviral, antibacterial, antifungal activities and cytotoxicity
• its effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model
• its effect on liver toxication induced by Fumonisin B1 in mice

Actions biochimiques/physiologiques

Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.

Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.

Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin.

Autres remarques

Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)