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P9115

Sigma-Aldrich

Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt

≥90% (HPLC), lyophilized powder

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About This Item

Formule empirique (notation de Hill):
C53H98N20O12 · C2HF3O2
Poids moléculaire :
1321.50
Numéro MDL:
MFCD03788010
Code UNSPSC :
12352204
ID de substance PubChem :
329820342
Nomenclature NACRES :
NA.32

Niveau de qualité

100

Pureté

≥90% (HPLC)

Forme

lyophilized powder

Solubilité

H2O: soluble

Température de stockage

−20°C

Chaîne SMILES 

OC(=O)C(F)(F)F.CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

InChI

1S/C53H100N20O12.C2HF3O2/c1-6-8-9-10-11-12-13-14-15-16-17-24-39(76)65-29-40(77)69-35(22-19-26-63-52(58)59)48(83)73-43(33(5)74)50(85)66-30-41(78)68-34(21-18-25-62-51(56)57)46(81)70-36(23-20-27-64-53(60)61)47(82)71-37(28-38(54)75)49(84)67-32(4)45(80)72-42(44(55)79)31(3)7-2;3-2(4,5)1(6)7/h31-37,42-43,74H,6-30H2,1-5H3,(H2,54,75)(H2,55,79)(H,65,76)(H,66,85)(H,67,84)(H,68,78)(H,69,77)(H,70,81)(H,71,82)(H,72,80)(H,73,83)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64);(H,6,7)/t31-,32-,33+,34-,35-,36-,37-,42-,43-;/m0./s1

Clé InChI

DBHNUJXUTKVLID-UXBYPZMDSA-N

Informations sur le gène

human ... PRKACA(5566)
mouse ... PRKACA(18747)
rat ... PRKACA(25636)

Amino Acid Sequence

Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

Description générale

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt inhibits the protein kinase cAMP-activated catalytic subunit-α (PRKACA). The gene encoding it is localized on human chromosome 19p13.1.

Application

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt has been used in cell culture for pharmaceutical inhibition and activation studies.

Actions biochimiques/physiologiques

Mutations in the gene encoding protein kinase cAMP-activated catalytic subunit-α (PRKACA) have been associated with Cushing′s syndrome.
Cell permeable cAMP-dependent protein kinase (PKA) inhibitor

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Hang-Bing Dai et al.
Obesity (Silver Spring, Md.), 29(1), 86-97 (2020-09-29)
Adrenomedullin (ADM) possesses therapeutic potential for inflammatory diseases. Consequently, the effects of ADM on inflammation in visceral white adipose tissue (vWAT) of obese rats or in adipocytes were explored in this study. Male rats were fed a high-fat diet for
The gene encoding the catalytic subunit Ca of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13. 1
Kjetil Tasken
Genomics, 36.3 , 535-538 (1996)
The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility.
Di Zazzo E
TheScientificWorldJournal, 565839-565839 (2014)
Toru Shigeoka et al.
Journal of diabetes investigation, 11(5), 1137-1149 (2020-03-09)
Incretin therapy is a common treatment for type 2 diabetes mellitus. We have previously reported an anti-prostate cancer effect of glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4. The attenuation of cell proliferation in the prostate cancer cell line was dependent on GLP-1R
Juan J Ferreira et al.
Frontiers in cell and developmental biology, 9, 733653-733653 (2021-10-16)
To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization. In mouse epididymal sperm, membrane depolarization
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