P0184
Pseudomonas exotoxin A
from Pseudomonas aeruginosa, protein synthesis inhibitor, lyophilized powder
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Form:
lyophilized powder
Quality level:
Service technique
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Pseudomonas exotoxin A from Pseudomonas aeruginosa, lyophilized powder
form
lyophilized powder
Quality Level
composition
Protein, ~30% E1%/280
storage temp.
2-8°C
General description
Pseudomonas exotoxin A is secreted by Pseudomonas aeruginosa. It is a member of the family mono-ADP-ribosyltransferases.
Biochem/physiol Actions
Pseudomonas exotoxin A functions as an anticancer agent.
It catalyses the transfer of ADP-ribose moiety of NAD+ to the histidine imidazole ring of diphthamide.
Shown to be toxic to animals and to cell lines, and to inhibit protein synthesis via ADP ribosylation of elongation factor 2.
It catalyses the transfer of ADP-ribose moiety of NAD+ to the histidine imidazole ring of diphthamide.
Shown to be toxic to animals and to cell lines, and to inhibit protein synthesis via ADP ribosylation of elongation factor 2.
Packaging
Package size based on protein content.
Physical form
Lyophilized powder containing Tris buffer, EDTA, NaCl and lactose
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Contenu apparenté
Product Information Sheet
Pseudomonas exotoxin A: from virulence factor to anti-cancer agent
Wolf P and Elsasser-Beile U
International Journal of Medical Microbiology : IJMM, 299(3), 161-176 (2009)
B H Iglewski et al.
Infection and immunity, 15(1), 138-144 (1977-01-01)
Previous studies showed that Pseudomonas aeruginosa exotoxin A (PA toxin) catalyzes nicotinamide adenine dinucleotide (NAD)-dependent inhibition of protein synthesis in a rabbit reticulocyte lysate and transfer of radioactivity from [14C]adenine-labeled NAD to a protein having the same molecular weight as
Preparation of Pseudomonas exotoxin A.
K J Kozak et al.
Methods in enzymology, 165, 147-152 (1988-01-01)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| P0184-.5MG | 04061834290896 |