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M0627

Sigma-Aldrich

7-Methylguanosine

≥90%

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About This Item

Formule empirique (notation de Hill):
C11H15N5O5
Numéro CAS:
20244-86-4
Poids moléculaire :
297.27
Numéro Beilstein :
3713683
Numéro MDL:
MFCD16661197
Code UNSPSC :
41106305
ID de substance PubChem :
24896562
Nomenclature NACRES :
NA.51

Source biologique

synthetic

Niveau de qualité

200

Pureté

≥90%

Forme

powder

Solubilité

water: 50 mg/mL, clear to hazy, colorless to faintly yellow

Température de stockage

2-8°C

Chaîne SMILES 

C[n+]1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c3nc(N)nc([O-])c13

InChI

1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/t4-,6-,7-,10-/m1/s1

Clé InChI

OGHAROSJZRTIOK-KQYNXXCUSA-N

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Description générale

7-Methylguanosine structure is also referred to as a cap. It is located on the 5′ end of the cytoplasmic mRNA.

Application

7-Methylguanosine has been used in the removal of residual phosphates from pre rigor solution, phosphate mop system and phosphorous standard solution.

Actions biochimiques/physiologiques

7-Methylguanosine is involved in the processing of a cap-dependent translational process of mRNA. It is also involved in protecting the mRNA from degradation due to ribonucleases and mediate nuclear export. 7-Methylguanosine also permits the recruitment of ribosome.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Nicolas Leulliot et al.
Structure (London, England : 1993), 16(1), 52-61 (2008-01-11)
Loss of N7-methylguanosine (m7G) modification is involved in the recently discovered rapid tRNA degradation pathway. In yeast, this modification is catalyzed by the heterodimeric complex composed of a catalytic subunit Trm8 and a noncatalytic subunit Trm82. We have solved the
Jinpeng Gao et al.
Plant physiology, 174(3), 1713-1727 (2017-05-13)
Chilling stress is a major factor limiting plant development and crop productivity. Because the plant response to chilling is so complex, we are far from understanding the genes important in the response to chilling. To identify new genes important in
Akiko Ogawa et al.
STAR protocols, 2(4), 100848-100848 (2021-10-09)
About 150 modifications have been identified in RNA species. Besides their regulatory roles in the intracellular gene expression, abundant modified RNA nucleosides are catabolized from RNA and released into extracellular fluids, which can impact extracellular signaling as ligands for receptors.
G Hu et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(13), 7149-7154 (1999-06-23)
We have determined, by high resolution x-ray analysis, 10 structures comprising the mRNA cap-specific methyltransferase VP39 or specific mutants thereof in the presence of methylated nucleobase analogs (N1-methyladenine, N3-methyladenine, N1-methylcytosine, N3-methylcytosine) and their unmethylated counterparts, or nucleoside N7-methylguanosine. Together with
Esther Z Chen et al.
Investigational new drugs, 32(4), 598-603 (2014-04-09)
Deranged cap-mediated translation is implicated in the genesis, maintenance and progression of many human cancers including mesothelioma. In this study, disrupting the eIF4F complex by antagonizing the eIF4E-mRNA-cap interaction is assessed as a therapy for mesothelioma. Mesothelioma cells were treated
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