K0253
Keratin from human epidermis
aqueous solution
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About This Item
Produits recommandés
Source biologique
human epidermis
Niveau de qualité
Essai
≥90% (SDS-PAGE)
Forme
urea solution
Technique(s)
ELISA: suitable
Numéro d'accès UniProt
Température de stockage
2-8°C
Informations sur le gène
human ... KRT1(3848)
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Description générale
Keratins are characteristic intermediate filament proteins of the epithelia. In human, keratin is classified into type I and type II. About 54 genes encodes for the keratin protein. The keratin 1 (KRT1) gene is mapped to human chromosome 12q13.13. It is the primary component of hair, skin and nails.
Application
Keratin from human epidermis has been used:
- as an analyte and a cross-reactant in the antibody-immobilized chip for testing selectivity coefficients
- as a standard in extracellular matrix (ECM) protein in in vitro protein degradation assays.
- asa a standard in enzyme linked immunosorbent assay (ELISA)
Actions biochimiques/physiologiques
Keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis. This diverse group of cytoskeletal scaffolding proteins form intermediate filament networks which provide structural support to keratinocytes that maintain the integrity of the skin. Expression of keratin genes is usually regulated by differentiation of the epidermal cells within the stratifying squamous epithelium.
Forme physique
Solution in 8 M urea, 50 mM Tris, 0.1 M β-mercaptoethanol and 0.1% sodium azide, pH 8.4
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Skin Sens. 1
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
N O Ku et al.
The Journal of cell biology, 143(7), 2023-2032 (1998-12-29)
Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate filament (IF) proteins. One important physiologic function of K8/18 is to protect hepatocytes from drug-induced liver injury. Although the mechanism of this protection is unknown, marked K8/18
Next-generation sequencing detection and characterization of a heterozygous novel splice junction mutation in the 2B domain of KRT1 in a family with diffuse palmoplantar keratoderma
Banerjee S, et al.
Experimental Dermatology, 24(2), 152-155 (2015)
Jyh-Hong Lee et al.
Journal of biomedical optics, 14(1), 014008-014008 (2009-03-05)
Atopic dermatitis (AD) is characterized by hyperkeratosis of epidermis and fibrosis within dermis in chronic skin lesions. Thus far, the histology of skin lesions has been evaluated only by examination of excised specimens. A noninvasive in vivo tool is essential
Francesca Angiero et al.
Anticancer research, 33(6), 2673-2677 (2013-06-12)
The adenomatoid odontogenic tumor (AOT) is an uncommon tumor of odontogenic origin, composed of odontogenic epithelium and characterized by slow but progressive growth. We report a rare case of AOT in an 18-year-old, who presented with a palpable bony-hard swelling
B B Hogans et al.
Journal of cellular physiology, 137(2), 346-352 (1988-11-01)
To determine whether activation of protein kinase C is involved in the proliferation of interleukin-3 (IL-3) -dependent cells, we examined the effect of tumor-promoting phorbol esters on the in vitro proliferation of the IL-3-dependent cell lines FD and DA-1. The
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