G3381

Geldanamycin from Streptomyces hygroscopicus

≥98% (HPLC), powder

• Synonyme(s) : NSC 122750
• Formule empirique (notation de Hill): C₂₉H₄₀N₂O₉
• Numéro CAS: 30562-34-6
• Poids moléculaire : 560.64
• Numéro MDL: MFCD00274570
• Code UNSPSC : 12352200
• ID de substance PubChem : 329799914
• Nomenclature NACRES : NA.77

Propriétés

• Stérilité: non-sterile
• Niveau de qualité: 300
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: yellow to orange
• Solubilité: DMSO: soluble
• Spectre d'activité de l'antibiotique: neoplastics
• Mode d’action: enzyme | inhibits
• Température de stockage: −20°C
• Chaîne SMILES: CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
• Clé InChI: QTQAWLPCGQOSGP-KSRBKZBZSA-N

Description

Description générale

Chemical structure: benzenoid

Actions biochimiques/physiologiques

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.
Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)