G111000

DMT-dG(ib) Phosphoramidite

• Synonyme(s) : N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
• Formule empirique (notation de Hill): C₄₄H₅₄N₇O₈P
• Numéro CAS: 93183-15-4
• Poids moléculaire : 839.92
• Numéro MDL: MFCD00055147
• Code UNSPSC : 41116107
• ID de substance PubChem : 329799720
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: non-animal source (no BSE/TSE risk)
• Niveau de qualité: 200
• Type: for DNA synthesis
• Gamme de produits: Proligo Reagents
• Pureté: ≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
• Forme: powder or granules
• Technique(s): oligo synthesis: suitable
• Impuretés: ≤0.3 wt. % water content (Karl Fischer)
• Couleur: white to off-white
• λ: conforms (UV/VIS Identity)
• Profil des nucléosides: base: deoxyguanosine; base protecting group: isobutyryl; 2' protecting group: none; 5' protecting group: DMT; deprotection: standard
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(=O)NC(NC(=O)C(C)C)=Nc34)(c5ccccc5)c6ccc(OC)cc6
• InChI: 1S/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,48,49,52,53)/t36-,37+,38+,60?/m0/s1
• Clé InChI: FDRMKYVTIFSDPR-MMROLVBFSA-N

Description

Description générale

DMT-dG(ib) Phosphoramidite belongs to the group of DNA Phosphoramidites.Its key features include:

• Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution,for standard base-protected oligonucleotides
• The high coupling efficiency of Proligo′s DNA phosphoramidites leads tohigh-yield and high-quality oligonucleotides