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F5259

Sigma-Aldrich

Anti-Human IgA (α-chain specific)−FITC antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Goat Anti-Human IgA (α-chain specific)−Fluorescein isothiocyanate

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About This Item

Numéro MDL:
MFCD00162415
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

goat

Niveau de qualité

200

Conjugué

FITC conjugate

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

secondary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Technique(s)

direct immunofluorescence: 1:16

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

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Description générale

IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. Thus secretory IgA contributes to the humoral defense mechanism against the pathogens on mucosal surfaces
Anti-Human IgA (α-chain specific)-FITC antibody is specific for α chain of human IgA. Goat Anti-Human IgA is conjugated to Fluorescein Isothiocyanate (FITC), Isomer I.

Immunogène

Purified human IgA

Application

Anti-Human IgA (α-chain specific)-FITC antibody may be used for direct immunofluorescence at a working antibody dilution of 1:16 to 1:32. A dilution of 1:100 was used for immunohistochemistry of cryosections of human sural nerves.

Forme physique

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 1% BSA and 15 mM sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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G B Rosoklija et al.
Acta neuropathologica, 99(1), 55-62 (2000-01-29)
Quantitative immunocytochemical analysis of complement proteins (CP) was performed on sural nerve biopsies from 15 patients with diabetic neuropathy (DN) and 18 nondiabetic patients with other forms of chronic neuropathy (ON). The mean age of the patients and the pathological
Clayton A White et al.
Journal of immunology (Baltimore, Md. : 1950), 193(12), 5933-5950 (2014-11-14)
Class-switch DNA recombination (CSR) and somatic hypermutation (SHM), which require activation-induced cytidine deaminase (AID), and plasma cell differentiation, which requires B lymphocyte-induced maturation protein-1 (Blimp-1), are critical for the generation of class-switched and hypermutated (mature) Ab and autoantibody responses. We
Helia N Sanchez et al.
Nature communications, 11(1), 60-60 (2020-01-04)
Short-chain fatty acids (SCFAs) butyrate and propionate are metabolites from dietary fiber's fermentation by gut microbiota that can affect differentiation or functions of T cells, macrophages and dendritic cells. We show here that at low doses these SCFAs directly impact B
Siril S Bakke et al.
Journal of immunology (Baltimore, Md. : 1950), 199(8), 2910-2920 (2017-09-01)
Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a compound that solubilizes lipophilic substances. Recently we have shown that BCD has an anti-inflammatory effect
Valeria R Villella et al.
The EMBO journal, 38(2) (2018-12-01)
Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world population, gluten proteins from wheat and related cereals trigger an HLA DQ2/8-restricted TH1 immune and antibody response leading
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