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D8008

Sigma-Aldrich

7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid

≥95%

Synonyme(s) :

DEDA

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About This Item

Formule empirique (notation de Hill):
C22H40O2
Numéro CAS:
89560-01-0
Poids moléculaire :
336.55
Numéro MDL:
MFCD00133010
Code UNSPSC :
12352202
ID de substance PubChem :
24278388

Source biologique

synthetic (organic)

Pureté

≥95%

Forme

liquid

Température de stockage

−20°C

Chaîne SMILES 

CCCCCCCCCCC\C=C/C(C)(C)\C=C/CCCC(O)=O

InChI

1S/C22H40O2/c1-4-5-6-7-8-9-10-11-12-13-16-19-22(2,3)20-17-14-15-18-21(23)24/h16-17,19-20H,4-15,18H2,1-3H3,(H,23,24)/b19-16-,20-17-

Clé InChI

AGKRHAILCPYNFH-DUQSFWPASA-N

Informations sur le gène

human ... ADORA2A(135) , ADORA2B(136)

Actions biochimiques/physiologiques

Inhibitor of phospholipase A2 and lipoxygenase. Inhibits endogenous synthesis of leukotrienes.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Espen Mariussen et al.
Toxicology and applied pharmacology, 179(3), 137-144 (2002-03-22)
Polychlorinated biphenyls (PCBs) are widespread persistent environmental contaminants that display a complex spectrum of toxicological properties, including neurotoxicity. The present study investigates the effects of the PCB mixtures Aroclor 1242 (A1242) and Aroclor 1254 (A1254), and the PCB congeners 126
S Huang et al.
Kidney international, 55(5), 1740-1749 (1999-05-07)
We have studied interleukin-1 (IL-1)-stimulated signals and gene expression in mesangial cells (MCs) to identify molecular mechanisms of MC activation, a process characteristic of glomerular inflammation. The JNK1 pathway has been implicated in cell fate decisions, and IL-1 stimulates the
C S Ramesha et al.
Analytical biochemistry, 192(1), 173-180 (1991-01-01)
a simple gas chromatographic method for the assay of phospholipase A2 (PLA2) has been described in which arachidonic acid released from endogenous phospholipid pools is measured following its extraction and derivatization to pentafluorobenzyl esters. Using this assay, PLA2 activities in
D G Johns et al.
The American journal of physiology, 275(5 Pt 2), H1592-H1598 (1998-11-14)
Ceramide is a novel second messenger generated by hydrolysis of membrane sphingomyelin by a neutral sphingomyelinase (nSMase). Cytokines such as tumor necrosis factor-alpha (TNF-alpha) have been shown to increase intracellular ceramide through phospholipase A2 (PLA2)-dependent activation of nSMase. TNF-alpha has
Yinchun Jiao et al.
Molecules (Basel, Switzerland), 25(18) (2020-09-10)
We show that natural bond orbital (NBO) and natural resonance theory (NRT) analysis methods provide both optimized Lewis-structural bonding descriptors for ground-state electronic properties as well as suitable building blocks for idealized "diabatic" two-state models of the associated spectroscopic excitations.
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