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C7397

Sigma-Aldrich

Cyclophosphamide monohydrate

ISOPAC®

Synonyme(s) :

2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan

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About This Item

Formule empirique (notation de Hill):
C7H15Cl2N2O2P · H2O
Numéro CAS:
6055-19-2
Poids moléculaire :
279.10
Numéro Beilstein :
4678992
Numéro CE :
200-015-4
Numéro MDL:
MFCD00149395
Code UNSPSC :
51112507
ID de substance PubChem :
24892961
Nomenclature NACRES :
NA.25

Pureté

97.0-103.0% (HPLC)

Forme

powder

Pf

49-51 °C (lit.)

Température de stockage

2-8°C

Chaîne SMILES 

[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1

InChI

1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

Clé InChI

PWOQRKCAHTVFLB-UHFFFAOYSA-N

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Application

Cyclophosphamide, a nitrogen mustard DNA alkylating agent, is used to study its mechanisms of action as an anticancer and antiimmunity drug.

Actions biochimiques/physiologiques

Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.

Conditionnement

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.

Attention

Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.

Reconstitution

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Informations légales

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC de

Réf. du produit
Description
Tarif

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301,H340,H350,H360FD

Classification des risques

Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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