C7397
Cyclophosphamide monohydrate
ISOPAC®
Synonyme(s) :
2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
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A propos de cet article
Formule empirique (notation de Hill) :
C7H15Cl2N2O2P · H2O
Numéro CAS:
Poids moléculaire :
279.10
UNSPSC Code:
51112507
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-015-4
Beilstein/REAXYS Number:
4678992
MDL number:
Assay:
97.0-103.0% (HPLC)
Form:
powder
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assay
97.0-103.0% (HPLC)
form
powder
mp
49-51 °C (lit.)
storage temp.
2-8°C
SMILES string
[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1
InChI
1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
InChI key
PWOQRKCAHTVFLB-UHFFFAOYSA-N
Application
Cyclophosphamide, a nitrogen mustard DNA alkylating agent, is used to study its mechanisms of action as an anticancer and antiimmunity drug.
Biochem/physiol Actions
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.
Packaging
Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.
Preparation Note
Dissolving the contents in 100 mL of solvent yields a 1% solution.
Legal Information
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.
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Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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