C1230

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone

≥90% (TLC), powder

• Synonyme(s) : Z-IETD-FMK
• Formule empirique (notation de Hill) : C₃₀H₄₃FN₄O₁₁
• Numéro CAS: 220760-26-9
• Poids moléculaire : 654.68
• NACRES: NA.77
• PubChem Substance ID: 329774744
• UNSPSC Code: 12352209
• MDL number: MFCD01861686
• Assay: ≥90% (TLC)
• Form: powder

Propriétés

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥90% (TLC)
• form: powder
• solubility: methanol: 10 mg/mL, DMSO: 20 mM, clear, colorless to light yellow
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF
• InChI: 1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1
• InChI key: CTXDBLYOEUERAT-VUVYEONESA-N

Description

Application

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:

• to study the activity of caspase-8 in porcine kidney cells
• to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
• to study its effects on retinal ganglion and astroglia in rat eyes

Biochem/physiol Actions

Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)