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A4477

Sigma-Aldrich

Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer845) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

Synonyme(s) :

Anti-phospho-AMPA Glutamate Receptor 1 (pSer845)

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About This Item

Numéro MDL:
MFCD04040523
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous glycerol solution

Poids mol.

antigen 100 kDa

Espèces réactives

human, rat

Technique(s)

dot blot: 1:1000
western blot: 1:1,000 using rat brain extracts

Numéro d'accès UniProt

P42261

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer845)

Informations sur le gène

human ... GRIA1(2890)
rat ... Gria1(50592)

Description générale

Rabbit Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer845) antibody recognizes human and rat AMPA Receptor, GluR1 subunit (pSer845).

Immunogène

synthetic phosphorylated peptide corresponding to a region near serine 845 of rat glutamate receptor subunit GluR1.

Application

Rabbit Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer845) antibody can be used for western blot analysis at 1:1,000 using rat brain extracts.

Description de la cible

AMPA is a transmembrane receptor for glutamate that regulates synapsis in the central nervous system. It is composed of 4 types of subunits, GluR1, 2, 3, 4.

Forme physique

Solution in 10 mM HEPES buffer, pH 7.5, containing 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Rodrigo Bainy Leal et al.
Molecular psychiatry, 25(3), 655-665 (2018-06-09)
Fear is a conscious state caused by exposure to real or imagined threats that trigger stress responses that affect the body and brain, particularly limbic structures. A sub-group of patients with mesial temporal lobe epilepsy related to hippocampus sclerosis (MTLE-HS)
Kuang-Ti Chen et al.
Frontiers in behavioral neuroscience, 9, 162-162 (2015-07-08)
Sarcosine, an endogenous amino acid, is a competitive inhibitor of the type I glycine transporter and an N-methyl-d-aspartate receptor (NMDAR) coagonist. Recently, we found that sarcosine, an NMDAR enhancer, can improve depression-related behaviors in rodents and humans. This result differs
Loukia Parisiadou et al.
Nature neuroscience, 17(3), 367-376 (2014-01-28)
Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with
M W Lopes et al.
Translational psychiatry, 6(12), e986-e986 (2016-12-14)
Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly in the limbic circuits that modulates cognition, emotion and behavior. GC are the most commonly prescribed anti-inflammatory and immunosuppressant medication worldwide and pharmacological GC treatment

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