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Merck
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Documents

A0779

Sigma-Aldrich

p-Aminoclonidine hydrochloride

solid

Synonyme(s) :

2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride, Apraclonidine hydrochloride

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About This Item

Formule empirique (notation de Hill):
C9H10Cl2N4 · xHCl
Poids moléculaire :
245.11 (free base basis)
Numéro MDL:
MFCD00135922
Code UNSPSC :
12352200
ID de substance PubChem :
24277751
Nomenclature NACRES :
NA.77

Forme

solid

Niveau de qualité

100

Couleur

white

Solubilité

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL (Solutions may be stored for several days at 4 °C)
boiling water: 100 mg/mL (Solutions may be stored for several days at 4 °C)
0.1 M HCl: soluble (Solutions may be stored for several days at 4 °C)
methanol: soluble (Solutions may be stored for several days at 4 °C)

Température de stockage

2-8°C

Chaîne SMILES 

Cl[H].Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1

InChI

1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2,12H2,(H2,13,14,15);1H

Clé InChI

OTQYGBJVDRBCHC-UHFFFAOYSA-N

Informations sur le gène

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Actions biochimiques/physiologiques

α2-adrenoceptor agonist.

Caractéristiques et avantages

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301 + H311 + H331

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

J Cepelík et al.
Physiological research, 46(3), 203-208 (1997-01-01)
The effects of the selective alpha2-adrenergic agonist p-aminoclonidine, the nonselective adrenergic agonist epinephrine, the selective beta2-adrenergic agonist fenoterol and the adenosine A1 agonist R-PIA on intraocular pressure were studied in control and pertussis toxin-pretreated rabbits. Pretreatment of rabbits with pertussis
T Salminen et al.
The Journal of biological chemistry, 274(33), 23405-23413 (1999-08-07)
We have compared bacteriorhodopsin-based (alpha(2A)-AR(BR)) and rhodopsin-based (alpha(2A)-AR(R)) models of the human alpha(2A)-adrenengic receptor (alpha(2A)-AR) using both docking simulations and experimental receptor alkylation studies with chloroethylclonidine and 2-aminoethyl methanethiosulfonate hydrobromide. The results indicate that the alpha(2A)-AR(R) model provides a better
M E Alburges et al.
Brain research bulletin, 32(2), 97-102 (1993-01-01)
The localization of alpha 2-receptors was determined by quantitative autoradiography using [125I]para-iodoclonidine ([125I]PIC) and [3H]para-aminoclonidine ([3H]PAC). In cortical tissue, [125I]PIC and [3H]PAC were equipotent in their capacity to bind sites recognized by oxymetazoline (preferentially binds to the alpha 2A receptor

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