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Y0001243

Folic acid impurity D

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Pteroic acid

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About This Item

Formule empirique (notation de Hill):
C14H12N6O3
Numéro CAS:
119-24-4
Poids moléculaire :
312.28
Numéro MDL:
MFCD00075823
Code UNSPSC :
41116107
ID de substance PubChem :
329831320
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

folic acid

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

NC1=NC(=O)C2=NC(CNc3ccc(cc3)C(O)=O)=CNC2=N1

InChI

1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)

Clé InChI

JOAQINSXLLMRCV-UHFFFAOYSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Folic acid impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

F0300000

Folic acid, European Pharmacopoeia (EP) Reference Standard

PHR1035

Folic acid, Pharmaceutical Secondary Standard; Certified Reference Material

1286005

Folic acid, United States Pharmacopeia (USP) Reference Standard

Y0001242

Folic acid impurity A, European Pharmacopoeia (EP) Reference Standard

C0250000

Calcium folinate, European Pharmacopoeia (EP) Reference Standard

PHR1334

Folic Acid Impurity A, Pharmaceutical Secondary Standard; Certified Reference Material

1286027

Folic Acid Related Compound A, United States Pharmacopeia (USP) Reference Standard

1286300

10-Formylfolic acid, United States Pharmacopeia (USP) Reference Standard

1019870

4-Aminobenzoylglutamic acid, United States Pharmacopeia (USP) Reference Standard

BP937

Folic acid, British Pharmacopoeia (BP) Reference Standard

Y0001979

Folic acid for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001980

Folic acid for impurity I identification, European Pharmacopoeia (EP) Reference Standard

PHR2001

Folic Acid Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

Y0002071

Calcium folinate for system suitability, European Pharmacopoeia (EP) Reference Standard

PHR2003

Folic Acid Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2334

10-Formylfolic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Berit Kühle et al.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 194, 257-267 (2012-08-25)
The folate receptor (FR) is a very attractive target in oncological imaging as it is overexpressed by a variety of cancer types, whereas the expression in healthy tissue is very limited. The synthesis of regioisomeric pure folic acid derivatives normally
P J Vickers et al.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 63(7), 777-779 (1985-07-01)
The glutamylation of methotrexate catalyzed by beef liver folypolyglutamate synthetase (FPGS) is activated by addition of pteroic acid. Pteroic acid causes greater stimulation of FPGS, including glutamylation of tetrahydrofolate, at neutral pH values (i.e., below the pH optimum of 8.4).
Synthesis of pteroylglutamic acid (liver L. casei factor) and pteroic acid.
C W WALLER et al.
Journal of the American Chemical Society, 70(1), 19-22 (1948-01-01)
Synthesis of pteroylglutamic acid (liver L. casei factor) and pteroic acid.
M E HULTQUIST et al.
Journal of the American Chemical Society, 70(1), 23-23 (1948-01-01)
Sumith A Kularatne et al.
Methods in molecular biology (Clifton, N.J.), 624, 249-265 (2010-03-11)
Nanoparticulate medicines offer the advantage of allowing delivery of large quantities of unmodified drug within the same particle. Nanoparticle uptake by cancer cells can, however, be compromised due to the large size and hydrophilicity of the particle. To circumvent cell
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