PHR1331
Metformin Related Compound A
Pharmaceutical Secondary Standard; Certified Reference Material
Synonyme(s) :
Dicyandiamide, Cyanoguanidine, Dicyanodiamide
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About This Item
Formule linéaire :
NH2C(=NH)NHCN
Numéro CAS:
Poids moléculaire :
84.08
Numéro Beilstein :
605637
Numéro CE :
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
Produits recommandés
Qualité
certified reference material
pharmaceutical secondary standard
Niveau de qualité
Agence
traceable to USP 1396310
Famille d'API
metformin
CofA (certificat d'analyse)
current certificate can be downloaded
Technique(s)
HPLC: suitable
gas chromatography (GC): suitable
Pf
208-211 °C (lit.)
Application(s)
pharmaceutical (small molecule)
Format
neat
Température de stockage
2-8°C
Chaîne SMILES
NC(=N)NC#N
InChI
1S/C2H4N4/c3-1-6-2(4)5/h(H4,4,5,6)
Clé InChI
QGBSISYHAICWAH-UHFFFAOYSA-N
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Description générale
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the widely used antidiabetic drug, metformin, that belongs to the biguanide class of compounds.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
It is an impurity of the widely used antidiabetic drug, metformin, that belongs to the biguanide class of compounds.
Application
This pharmaceutical secondary standard can also be used as follows:
- Separation and estimation of metformin along with other antidiabetics from meglitinides class in the presence of metformin impurity cyanoguanidine using a liquid chromatography method in pharmaceutical formulations
- Development of a reversed phase-high performance liquid chromatographic (RP-HPLC) method combined with a UV-diode array detector (PDA) for the impurity analysis of combined dosage tablet of metformin hydrochloride and teneligliptin hydrobromide hydrate
- Estimation of empagliflozin, linagliptin, along with metformin and its related impurities cyanoguanidine and melamine using HPLC-DAD and high-performance thin layer chromatography (HPTLC) methods in their combined tablets
- Development and validation of a stability indicating capillary zone electrophoresis (CZE) method for the quantification of metformin and its major impurity in pharmaceutical formulation
- Simultaneous determination of vildagliptin, metformin, and metformin-related compounds (A, B, and C) in tablets using a high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS)
Remarque sur l'analyse
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Note de bas de page
To see an example of a Certificate of Analysis for this material enter LRAA0834 in the slot below. This is an example certificate only and may not be the lot that you receive.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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HPLC-MS/MS method for simultaneous quantification of vildagliptin, metformin, and metformin-related compounds in tablets
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