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Key Documents

PHR1055

Supelco

Famotidine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

{3-[((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio]-N′-(aminosulfonyl)propaneimidamide}, N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine

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About This Item

Formule empirique (notation de Hill):
C8H15N7O2S3
Numéro CAS:
Poids moléculaire :
337.45
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Source biologique

synthetic

Niveau de qualité

Qualité

certified reference material
pharmaceutical secondary standard

Agence

BP
EP
USP
traceable to BP 653
traceable to Ph. Eur. F0050000
traceable to USP 1269200

Pression de vapeur

<0.0000001 kPa ( 25 °C)

Famille d'API

famotidine

CofA (certificat d'analyse)

current certificate can be downloaded

Conditionnement

pkg of 1 g

Conditions de stockage

protect from light (20 mm aluminium crimp seal for unused portion)

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Couleur

white to pale yellow-white

Pf

325.4-327.2 °F (163—164°C)

Solubilité

DMF: freely soluble
acetone: practically insoluble
chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
ethyl acetate: practically insoluble
glacial acetic acid: freely soluble
methanol: slightly soluble
water: very slightly soluble

Application(s)

pharmaceutical (small molecule)

Format

neat

Conditions d'expédition

ambient

Température de stockage

2-8°C

Chaîne SMILES 

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

Clé InChI

XUFQPHANEAPEMJ-UHFFFAOYSA-N

Informations sur le gène

human ... HRH2(3274)

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Description générale

Famotidine is a histamine H2-receptor antagonist, which promotes the healing of erosive esophagitis, gastric and duodenal ulcers since it inhibits the gastric acid secretion in humans.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Famotidine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Actions biochimiques/physiologiques

H2 histamine receptor antagonist; anti-ulcer agent

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAA7133 in the slot below. This is an example certificate only and may not be the lot that you receive.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Certificats d'analyse (COA)

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Les clients ont également consulté

The
Profiles of Drug Substances, Excipients, and Related Methodology (2011)
GC Determination of famotidine, ranitidine, cimetidine, and metformin in pharmaceutical preparations and serum using methylglyoxal as derivatizing reagent
Majidano AS, et al.
Chromatographia, 75(21-22), 1311-1317 (2012)
Hideto Yano et al.
Circulation journal : official journal of the Japanese Circulation Society, 76(11), 2673-2680 (2012-08-07)
It remains unclear whether concomitant use of omeprazole attenuates platelet function as compared with that of famotidine in patients with acute coronary syndromes (ACS) who receive clopidogrel. In this prospective study, 130 ACS patients treated with aspirin and clopidogrel who
S Takayama et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 63(1), 41-52 (2012-03-31)
We set up a new model of gastric bleeding induced by the luminal perfusion of aspirin (ASA) in rats pretreated with clopidogrel under conditions where acid secretion is stimulated, and examined the effect of antiulcer drugs on the bleeding. Under
High-performance thin-layer chromatography for the determination of ranitidine hydrochloride and famotidine in pharmaceuticals.
Novakovic J.
Journal of Chromatography A, 846(1-2), 193-198 (1999)

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