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Principaux documents

E2503004

Etomidate impurity B

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Methyl 1-[(1RS)-1-phenylethyl]-1H-imidazole-5-carboxylate

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About This Item

Formule empirique (notation de Hill):
C13H14N2O2
Numéro CAS:
5377-20-8
Poids moléculaire :
230.26
Numéro MDL:
MFCD01721714
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

etomidate

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

[n]2(cncc2C(=O)OC)C(C)c1ccccc1

InChI

1S/C13H14N2O2/c1-10(11-6-4-3-5-7-11)15-9-14-8-12(15)13(16)17-2/h3-10H,1-2H3

Clé InChI

FHFZEKYDSVTYLL-UHFFFAOYSA-N

Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Etomidate impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Skull and crossbonesEnvironment
GHS06,GHS09

Mention d'avertissement

Danger

Mentions de danger

H301,H336,H411

Classification des risques

Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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J Hennings et al.
Langenbeck's archives of surgery, 395(7), 963-967 (2010-07-21)
To evaluate whether dexamethasone suppression treatment can improve (11) C-metomidate positron emission tomography (MTO-PET) detection of small adrenocortical adenomas in primary aldosteronism (PA). Eleven patients with proven PA and two patients with non-hyperfunctioning adrenocortical incidentalomas and small adrenocortical tumours observed
Heikki Minn et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 45(6), 972-979 (2004-06-08)
Our aim was to evaluate the use of PET with (11)C-metomidate and (18)F-FDG for the diagnosis of adrenal incidentalomas. Twenty-one patients underwent hormonal screening before dynamic imaging of the upper abdomen with (11)C-metomidate, and for 19 of these 21 patients
Georg Zettinig et al.
European journal of nuclear medicine and molecular imaging, 31(9), 1224-1230 (2004-06-16)
(11)C-metomidate (MTO), a marker of 11beta-hydroxylase, has been suggested as a novel positron emission tomography (PET) tracer for adrenocortical imaging. Up to now, experience with this very new tracer is limited. The aims of this study were (1) to evaluate
Joakim Hennings et al.
The Journal of clinical endocrinology and metabolism, 91(4), 1410-1414 (2006-01-13)
Adrenal incidentalomas are common findings necessitating extensive laboratory work-up and repetitive radiological examinations. Positron emission tomography (PET) using (11)C-labeled metomidate (MTO) has previously been described as a tool for specific adrenocortical imaging. We evaluated 212 MTO-PET examinations in 173 patients
Barbro Eriksson et al.
Annals of the New York Academy of Sciences, 970, 159-169 (2002-10-17)
Positron emission tomography (PET) supplies a range of labeled compounds to be used for the characterization of tumor biochemistry. Some of these have proved to be of value for clinical diagnosis, treatment follow up, and clinical research. The first routinely
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