MABT372
Anti-Mastl Antibody, clone 4F9
clone 4F9, from mouse
Synonyme(s) :
Serine/threonine-protein kinase greatwall, GW, GWL, hGWL, Microtubule-associated serine/threonine-protein kinase-like, MAST-L
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified antibody
Type de produit anticorps
primary antibodies
Clone
4F9, monoclonal
Espèces réactives
human
Technique(s)
immunohistochemistry: suitable
western blot: suitable
Isotype
IgG1κ
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... MASTL(84930)
Description générale
Mastl is also called Serine/threonine-protein kinase greatwall (GW) and Microtubule-associated serine/threonine-protein kinase-like (MAST-L). Mastl is a serine/threonine kinase that regulates mitosis entry and maintenance during M phase through the inactivation of protein phosphatase 2A (PP2A). Mastl is also thought to be involved in megakaryocyte differentiation and the diseaseThrombocytopenia 2 (THC2).
Immunogène
Epitope: C-terminus
Recombinant protein corresponding to the C-terminus of human Mastl.
Application
Detect Mastl using this mouse monoclonal antibody, Anti-Mastl Antibody, clone 4F9 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50-2,000 dilution from a representative lot detected Mastl in human prostate cancer and human testis tissue sections.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
Qualité
Evaluated by Western Blotting in human oral squamos cell carcinoma lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Mastl in 10 µg of human oral squamos cell carcinoma lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Mastl in 10 µg of human oral squamos cell carcinoma lysate.
Description de la cible
~97 kDa observed. Uncharacterized band(s) may appear in some lysates.
Forme physique
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Stockage et stabilité
Stable for 1 year at 2-8°C from date of receipt.
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Dario Hermida et al.
Molecular & cellular proteomics : MCP, 19(2), 326-343 (2019-12-20)
The human MASTL (Microtubule-associated serine/threonine kinase-like) gene encodes an essential protein in the cell cycle. MASTL is a key factor preventing early dephosphorylation of M-phase targets of Cdk1/CycB. Little is known about the mechanism of MASTL activation and regulation. MASTL
Odjo G Gouttia et al.
Frontiers in cell and developmental biology, 10, 904719-904719 (2022-10-18)
Platinum-based chemotherapy is the standard first-line treatment for oral squamous cell carcinoma (OSCC) that is inoperable, recurrent, or metastatic. Platinum sensitivity is a major determinant of patient survival in advanced OSCC. Here, we investigated the involvement of MASTL, a cell
Srijayaprakash Babu Uppada et al.
Molecular cancer, 17(1), 111-111 (2018-08-03)
Chemotherapeutic agents that modulate cell cycle checkpoints and/or tumor-specific pathways have shown immense promise in preclinical and clinical studies aimed at anti-cancer therapy. MASTL (Greatwall in Xenopus and Drosophila), a serine/threonine kinase controls the final G2/M checkpoint and prevents premature
Yanqiu Li et al.
eLife, 12 (2023-09-06)
Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing cyclin-dependent kinases (CDKs). However, it remains largely elusive how cell cycle recovery is initiated after DNA damage. In this study, we discovered the upregulated protein level of
Brittiny Dhital et al.
Cell reports. Medicine, 4(2), 100937-100937 (2023-02-15)
Metastatic prostate cancer (PCa) inevitably acquires resistance to standard therapy preceding lethality. Here, we unveil a chromosomal instability (CIN) tolerance mechanism as a therapeutic vulnerability of therapy-refractory lethal PCa. Through genomic and transcriptomic analysis of patient datasets, we find that
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