MABS64

Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2

clone 6E5.2, from mouse

• Synonyme(s) : mitogen-activated protein kinase 14, cytokine suppressive anti-inflammatory drug binding protein, stress-activated protein kinase 2A, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, MAP kinase MXI2, MAX-interacting pro
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Clone: 6E5.2, monoclonal
• Species reactivity: human, mouse
• Application: ICC, WB
• Citations: 9

Propriétés

• biological source: mouse
• Quality Segment: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 6E5.2, monoclonal
• species reactivity: human, mouse
• technique(s): immunocytochemistry: suitable, western blot: suitable
• NCBI accession no.: NP_001306.1
• UniProt accession no.: Q16539
• shipped in: wet ice
• target post-translational modification: phosphorylation (pThr180/pTyr182)
• Gene Information: human ... MAPK14(1432)

Description

General description

Poids réel (observé) : 41 kDa

The p38 family refers to the SAPK2/3 Kinases (Stess-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation.

Immunogen

Linear peptide corresponding to human p38 phosphorylated at Thr180 and Tyr182.

Épitope : Phosphorylated Thr180 and Tyr182

Application

&

Analyse par immunocytochimie : 1:500 dilution from a previous lot detected p38 in Anisomycin treated NIH/3T3 cells.

Domaine de recherche
Signalisation

Sous-domaine de recherche
MAP kinases

Biochem/physiol Actions

This antibody recognizes p38 when phosphorylated at Thr180 and Tyr182.

Physical form

κ

Format : Produit purifié

Produit purifié sur protéine G

Preparation Note

Stable entre 2 et 8 °C pendant 1 an à compter de la date de réception.

Analysis Note

µµ

Other Notes

Concentration : pour connaître la concentration spécifique du lot, voir le certificat d'analyse.

Disclaimer

Sauf indication contraire dans notre catalogue ou toute autre documentation associée au(x) produit(s), nos produits sont uniquement destinés à la recherche et ne sauraient être utilisés à d'autres fins, ce qui inclut, sans s'y limiter, les utilisations commerciales non autorisées, les utilisations diagnostiques in vitro, les utilisations thérapeutiques ex vivo ou in vivo, ou tout type de consommation ou d'application chez l'être humain ou chez l'animal.

Informations sur la sécurité

• Classe de stockage: 12 - Non Combustible Liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable