MABS445
Anti-Sclerostin Antibody, clone 7B6.1 | MABS445
culture supernatant, clone 7B6.1, from mouse
Synonyme(s) :
Sclerostin
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
culture supernatant
Type de produit anticorps
primary antibodies
Clone
7B6.1, monoclonal
Espèces réactives
rat, human
Technique(s)
immunohistochemistry: suitable
western blot: suitable
Isotype
IgG2bκ
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... SOST(50964)
Description générale
Sclerostin (UniProt Q9BQB4) is encoded by the SOST (also known as CDD, SOST1, VBCH) gene (ORP UNQ2976/PRO7455/PRO7476; Gene ID 50964) in human. Sclerostin is a glycoprotein expressed in osteocytes and functions as a negatively regulator against bone mass by antagonizing low density lipoprotein receptor-related proteins- (LRP5-/LRP6-) mediated WNT/beta-catenin pathway signaling. Sclerostin levels are increased in the post-menopausal women and elderly and in long term immobilized patients. Sclerostin neutralizing antibody is reported to enhance bone formation, mass, and strength in aged male rats. Sclerostin and its inhibitors have potential in prosthetic, regenerative and preventive therapy in dentistry.
Spécificité
Detects Sclerostin isoform 1 (UniProt Q9BQB4-1). Reactivity toward the spliced isoform 2 (UniProt Q9BQB4-2) is likely, but has not been determined.
Immunogène
Epitope: Internal
GST-tagged recombinant protein corresponding to the internal fragment of human Sclerostin.
Application
Anti-Sclerostin Antibody, clone 7B6.1 | MABS445 is an antibody against Sclerostin Antibody for use in Western Blotting and Immunohistochemistry.
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Sclerostin in human kidney, rat liver and human liver tissue.
Research Category
Signaling
Signaling
Research Sub Category
Developmental Signaling
Developmental Signaling
Qualité
Evaluated by Western Blotting in GST-tagged Sclerostin recombinant protein.
Western Blotting Analysis: A 1:500 dilution of this antibody detected 0.5 µg of GST-tagged Sclerostin recombinant protein.
Western Blotting Analysis: A 1:500 dilution of this antibody detected 0.5 µg of GST-tagged Sclerostin recombinant protein.
Description de la cible
24 kDa calculated
Forme physique
Mouse monoclonal IgG2bκ antibody tissue culture supernatant without preservatives.
Unpurified
Stockage et stabilité
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Autres remarques
Concentration: Please refer to lot specific datasheet.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Richard J Visconti et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(10), 1914-1930 (2021-06-27)
Human myeloma bone disease (MBD) occurs when malignant plasma cells migrate to the bone marrow and commence inimical interactions with stromal cells, disrupting the skeletal remodeling process. The myeloma cells simultaneously suppress osteoblastic bone formation while promoting excessive osteoclastic resorption.
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