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Key Documents

FCMAB418PE-I

Sigma-Aldrich

Milli-Mark® Anti-CAR-PE Antibody, clone RmcB

clone RmcB, Milli-Mark®, from mouse

Synonyme(s) :

46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3 binding protein, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, coxsackie virus B receptor, coxsackie virus and adenovirus receptor

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Conjugué

PE

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

RmcB, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Milli-Mark®

Technique(s)

flow cytometry: suitable

Isotype

IgG1

Numéro d'accès NCBI

NP_001329

Numéro d'accès UniProt

P78310

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CXADR(1525)

Catégories apparentées

Description générale

The coxsackievirus and adenovirus receptor (CAR) mediates cell attachment and infection by coxsackie B viruses and by a number of adenoviruses. CAR also mediates homotypic intercellular interactions. In polarized epithelial cells, CAR is closely associated with the tight junction, where it contributes to the barrier to paracellular flow of solutes and macromolecules. CAR′s biological roles are not well defined, but emerging evidence suggests that it may function during embryonic development and in regulating cell proliferation.

Spécificité

Antibody recognizes CAR.

Immunogène

Native human coxsackie virus-adenovirus receptor protein

Application

Detect CAR using this Milli-Mark Anti-CAR-PE Antibody, clone RmcB validated for use in FC.
Research Category
Cell Structure
Research Sub Category
ECM Proteins

Qualité

Evaluated by flow cytometry using HT-29 cells.

Description de la cible

40 kDa Calculated. Uniprot indicates multiple isoforms ranging from 9 to 40 kDa

Forme physique

Protein G Purified
Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Stockage et stabilité

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Remarque sur l'analyse

Control
HT-29 cells

Autres remarques

Unconjugated version Cat. No. 05-644 is known to react with Mouse and Rat.

Informations légales

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Michael Klichinsky et al.
Nature biotechnology, 38(8), 947-953 (2020-05-04)
Chimeric antigen receptor (CAR) T cell therapy has shown promise in hematologic malignancies, but its application to solid tumors has been challenging1-4. Given the unique effector functions of macrophages and their capacity to penetrate tumors5, we genetically engineered human macrophages
Hongkang Xi et al.
The Journal of experimental medicine, 213(2), 189-207 (2016-01-13)
Age-related macular degeneration (AMD), a leading cause of vision impairment in the ageing population, is characterized by irreversible loss of retinal pigment epithelial (RPE) cells and photoreceptors and can be associated with choroidal neovascularization. Mononuclear phagocytes are often present in

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