ABS535

Anti-Arginase-1 Antibody

from chicken

• Synonyme(s) : Type 1 Arginase ; ; ARG1
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: 15

Propriétés

• biological source: chicken
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: guinea pig, human, mouse, rat
• technique(s): immunohistochemistry: suitable, western blot: suitable
• isotype: IgY
• NCBI accession no.: NP_058830
• UniProt accession no.: P07824
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... ARG1(383) ; mouse ... Arg1(11846) ; rat ... Arg1(29221)

Description

General description

Arginase-1, the protein encoded by the ARG1 gene, is the enzyme that catalyzes the breakdown of L-arginine into ornithine and urea. ARG1 is a key player in the Urea cycle. There are two distinct isoforms of Arginase, Arginase I and Arginase II. Arginase I (also called the liver type arginase or Type 1 arginase) is a highly expressed cytosolic enzyme in the liver and other tissues, including the brain. Arginase II or kidney-type arginase is also widely expressed at low levels in many tissues but localized to the mitochondria primarily. Interestingly, Arginase 1 has neuroprotective properties. Arginase I is essential for protecting motor neurons from nitric oxide dependent apoptosis that can be induced upon cellular stress or trophic factor removal. By suppressing nitric oxide production, Arginase prevents the formation of peroxynitrite and its subsequent cellular toxicity. Furthermore, Arginase 1 appears to play critical roles throughout the CNS for survival and regeneration of neurons and axons. In cancer, Arginase 1, already a useful marker for hepatocytes is also an excellent marker for hepatocellular cancers.

Poids réel (observé) : env. 38 kDa

Immunogen

Full-length recombinant protein corresponding to Rat Arginase-1.

Application

Analyse par immunohistochimie : A representative lot detected Arginase-1 in bronchoalveolar lavage cells (Zimmermann, N., et al. (2003). –
A representative lot detected Arginase-1 in RAW cell lysate (Morris, S., et al. (1998). Am J Physiol Endocrinol Metab 275:E740-E747, 1998).

Domaine de recherche
Signalisation

This Anti-Arginase-1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Arginase-1.

Physical form

Format : Produit purifié

IgY purified from Yolk

Purified chicken Polyclonal other in buffer containing PBS with 0.05% sodium azide.

Preparation Note

Stable entre 2 et 8 °C pendant 1 an à compter de la date de réception.

Analysis Note

µµ

Other Notes

Concentration : Voir la fiche technique du lot concerné.

Disclaimer

Sauf indication contraire dans notre catalogue ou toute autre documentation associée au(x) produit(s), nos produits sont uniquement destinés à la recherche et ne sauraient être utilisés à d'autres fins, ce qui inclut, sans s'y limiter, les utilisations commerciales non autorisées, les utilisations diagnostiques in vitro, les utilisations thérapeutiques ex vivo ou in vivo, ou tout type de consommation ou d'application chez l'être humain ou chez l'animal.

Informations sur la sécurité

• Classe de stockage: 12 - Non Combustible Liquids
• wgk: WGK 2