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ABF108

Sigma-Aldrich

Anti-IL-33 Antibody

from rabbit, purified by affinity chromatography

Synonyme(s) :

Interleukin-33, IL-33, Interleukin-33(102-266), Interleukin-33(109-266)

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

mouse

Technique(s)

flow cytometry: suitable
western blot: suitable

Numéro d'accès NCBI

NP_598536

Numéro d'accès UniProt

Q8BVZ5

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

mouse ... Il33(77125)

Catégories apparentées

Description générale

IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor, leading to the activation of MAP kinases and NF-kappaB. IL-33 induces production of helper T-cell type 2 (TH2) cytokines, including IL-4, IL-5 and IL-13, and is a known mediator of many inflammation responses. Cat. No. ABF108, Anti-IL-33, is an affinity purified rabbit polyclonal antibody that recognizes epitopes in the C-terminal half of murine IL-33. Reactivity to rat or other species has not been tested.

Immunogène

Epitope: C-Terminal
His-tagged recombinant protein corresponding to the C-Terminal of mouse IL-33.

Application

Anti-IL-33 Antibody is an antibody against IL-33 for use in Western Blotting, Flow Cytometry.
Flow Cytometry Analysis: 0.25 µg of this antibody from a representative lot detected IL-33 in 1X10E6 monensin treated MEF1 cells.
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology

Qualité

Evaluated by Western Blotting in MEF1 cell lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected IL-33 in 10 µg of MEF1 cell lysate.

Description de la cible

~35 kDa observed. Uncharacterized band(s) may appear in some lysates.

Forme physique

Affinity
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Alaeddin Bashir Abukabda et al.
Particle and fibre toxicology, 15(1), 43-43 (2018-11-11)
The cardiovascular effects of pulmonary exposure to engineered nanomaterials (ENM) are poorly understood, and the reproductive consequences are even less understood. Inflammation remains the most frequently explored mechanism of ENM toxicity. However, the key mediators and steps between lung exposure
Jian-Fei Zhang et al.
Oncology reports, 38(4), 2033-2042 (2017-08-30)
As an important member of the interleukin (IL)-1 family, IL‑33 plays a significant role in tumor progression. To explore this, we previously analyzed the association between IL‑33 expression and the prognosis of patients with glioma. However, the function of the

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