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Key Documents

ABC139

Sigma-Aldrich

Anti-TSPO Antibody

from rabbit, purified by affinity chromatography

Synonyme(s) :

Translocator protein, Mitochondrial benzodiazepine receptor, PKBS, Peripheral-type benzodiazepine receptor, PBR

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

human

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TSPO(706)

Description générale

Translocator protein (TSPO) is also called Mitochondrial benzodiazepine receptor, PKBS, or Peripheral-type benzodiazepine receptor (PBR). TSPO generates peripheral-type benzodiazepine recognition sites. TSPO has a role in cholesterol transport across mitochondrial membranes in steroidogenic cells, and may also be involved in in the transport of porphyrins and heme. TSPO is found in many tissue types, but is normally found expressed at the highest levels in steroid synthesizing tissues.

Spécificité

This antibody recognizes the C-terminus of TSPO.

Immunogène

Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human TSPO.

Application

Anti-TSPO Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IHC.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected TSPO in 10 µg of HeLa cell lysate.
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected TSPO in human thalamus, human cardiac myocytes and human cerebellum tissue.

Qualité

Evaluated by Western Blotting in human testis tissue lysate.

Western Blotting Analysis: 0.25 µg/mL of this antibody detected TSPO in 10 µg of human testis tissue lysate.

Description de la cible

~16 kDa observed

Liaison

Replaces: MABC650

Forme physique

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Human testis tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Faheem Ullah et al.
Frontiers in neuroscience, 14, 170-170 (2020-04-01)
Chronic glial activation is characterized by an increased number of activated microglia and astroglia; these secrete free radicals and cytotoxic cytokines, subsequently causing neuronal damage. This study investigated the hypothesis that a soy-lecithin based phytosomal curcumin formulation can decrease glial
Faheem Ullah et al.
Scientific reports, 10(1), 2365-2365 (2020-02-13)
Chronic glial activation is characterized by increased numbers of activated glial cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity of Longvida® Optimised Curcumin (LC), we fed 500 ppm of LC to

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