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Merck
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Key Documents

05-675

Sigma-Aldrich

Anti-MBP Antibody, clone SKB3

clone SKB3, Upstate®, from mouse

Synonyme(s) :

Anti-C76307, Anti-Hmbpr, Anti-R75289, Anti-golli-mbp, Anti-jve, Anti-mld, Anti-shi

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

SKB3, monoclonal

Espèces réactives

rat, human, mouse

Fabricant/nom de marque

Upstate®

Technique(s)

western blot: suitable

Isotype

IgG1κ

Numéro d'accès NCBI

NM_002385

Numéro d'accès UniProt

P02686

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MBP(4155)
mouse ... Mbp(17196)
rat ... Mbp(24547)

Spécificité

Recognizes MBP.

Immunogène

Peptide corresponding to the human myelin basic protein sequence containing amino acid Thr98

Application

Detect MBP using this Anti-MBP Antibody, clone SKB3 validated for use in WB.
Research Category
Signaling
Research Sub Category
MAP Kinases

Qualité

routinely evaluated by immunoblot on RIPA lysates from mouse and rat brain tissue preparations

Description de la cible

18-20 kDa

Forme physique

Format: Purified
Protein G Purified
Protein G Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 0.02M Phosphate Buffer, 0.25 M NaCl, pH 7.6 with 15 mg/mL BSA containing no preservatives.

Stockage et stabilité

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Remarque sur l'analyse

Control
Brain tissue

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Monica Giannotta et al.
EMBO molecular medicine, 6(2), 239-258 (2014-01-01)
Muscular dystrophies are severe genetic diseases for which no efficacious therapies exist. Experimental clinical treatments include intra-arterial administration of vessel-associated stem cells, called mesoangioblasts (MABs). However, one of the limitations of this approach is the relatively low number of cells
Samantha K Barton et al.
Frontiers in neuroscience, 15, 705306-705306 (2021-09-21)
Pathological hallmarks of amyotrophic lateral sclerosis (ALS), including protein misfolding, are well established in oligodendrocytes. More recently, an RNA trafficking deficit of key myelin proteins has been suggested in oligodendrocytes in ALS but the extent to which this affects myelination
Robert Sparks et al.
The Journal of biological chemistry, 294(41), 14896-14910 (2019-08-16)
The metabolic consequences and sequelae of obesity promote life-threatening morbidities. PKCδI is an important elicitor of inflammation and apoptosis in adipocytes. Here we report increased PKCδI activation via release of its catalytic domain concurrent with increased expression of proinflammatory cytokines
Bangfu Zhu et al.
International journal of molecular sciences, 17(11) (2016-11-24)
The guided migration of neural cells is essential for repair in the central nervous system (CNS). Oligodendrocyte progenitor cells (OPCs) will normally migrate towards an injury site to re-sheath demyelinated axons; however the mechanisms underlying this process are not well
Cyclic AMP decreases the phosphorylation state of myelin basic proteins in rat brain cell cultures.
Ulmer, J B, et al.
The Journal of Biological Chemistry, 262, 1748-1755 (1987)
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Derivation of Functional Oligodendrocyte Progenitor Cells (OPCs) from Human Neural Stem Cell Lines

Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.

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