T-909

α-Hydroxytriazolam-d₄ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₁₇D₄H₈Cl₂N₄O
• Numéro CAS: 145225-01-0
• Poids moléculaire : 363.23
• Numéro CE : 200-659-6
• Numéro MDL: MFCD00673313
• Code UNSPSC : 41116107
• ID de substance PubChem : 329826898
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• Concentration: 100 μg/mL in methanol
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): clinical testing
• Format: single component solution
• Température de stockage: 2-8°C
• Chaîne SMILES: OCC1=NN=C2N1C3=CC=C(Cl)C=C3C(C4=C([2H])C([2H])=C([2H])C([2H])=C4Cl)=NC2
• InChI: 1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2/i1D,2D,3D,4D
• Clé InChI: BHUYWUDMVCLHND-RHQRLBAQSA-N

Description

Description générale

a-Hydroxytriazolam is a major urinary and blood metabolite of the benzodiazepine, triazolam, a pharmaceutical used to treat severe insomnia. This stable-labeled internal standard is suitable for triazolam testing or isotope dilution methods by GC/MS or LC/MS for clinical toxicology, urine drug testing, pain prescription monitoring or forensic analysis.

Application

• Pharmacokinetic Analysis of α-Hydroxytriazolam: A study focused on the urinary excretion of α-Hydroxytriazolam following a single dose of Halcion. This research provides critical insights into the metabolism of benzodiazepines, emphasizing the role of α-Hydroxytriazolam-d₄ as a stable isotope-labeled standard in tracing metabolic pathways in clinical pharmacology (Lin et al., 2005).


• Forensic Toxicology and Metabolite Confirmation: Another significant study utilized GC-MS to confirm the presence of urinary benzodiazepine metabolites, including α-Hydroxytriazolam. This research underscores the utility of α-Hydroxytriazolam-d₄ in forensic analysis, aiding in the detection and confirmation of benzodiazepine use and abuse in legal and medical settings (Meatherall, 1994).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup