810192P
Avanti
16:0-06:0 NBD PS
Avanti Research™ - A Croda Brand 810192P, powder
Synonyme(s) :
1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine (ammonium salt)
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About This Item
Formule empirique (notation de Hill):
C34H59N6O13P
Numéro CAS:
Poids moléculaire :
790.84
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25
Produits recommandés
Pureté
>99% (TLC)
Forme
powder
Conditionnement
pkg of 1 × 1 mg (810192P-1mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 810192P
Conditions d'expédition
dry ice
Température de stockage
−20°C
Description générale
Phosphatidylserine (PS) is a membrane phospholipid enriched in the cytosolic leaflet of plasma membrane. It comprises 2-10% of total phospholipids. NBD PS is a flurosently labelled phospholipid with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the headgroup of PS.
Application
16:0-06:0 NBD PS has been used as a labelled translocase to detect ATP-dependent translocation across late Golgi membranes. It is also suitable for analysis of phospholipid scramblase 1 (PLSCR1) scrambling in proteoliposomes and to determine enzyme specificity of lipoteichoic acid synthase enzyme (LtaS).
16:0-06:0 NBD PS or 1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoserine (ammonium salt) has been used in the 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) − phospholipase (PL) translocation assay to characterize an ATP-dependent flippase activity in yeast Golgi membranes. It may be used: to detect vesicular stomatitis virus G (VSV G) protein mediated cell-cell fusion, measure the enzyme substrate specificity of lipoteichoic acid (LTA) synthase (LtaS), in liposomes to determine the role of phospholipid scramblase 1 (PLSCR1) in phospholipid scrambling.
Actions biochimiques/physiologiques
Phosphatidylserine (PS) is involved in the regulation of many enzymes and structural components. It serves as an essential factor in the clearance of apoptotic cells. It is associated with cognitive disability in Alzheimer′s disease.
Conditionnement
5 mL Amber Glass Screw Cap Vial (810192P-1mg)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Code de la classe de stockage
11 - Combustible Solids
Certificats d'analyse (COA)
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An Unrecognized Function of Cholesterol: Regulating the Mechanism Controlling Membrane Phospholipid Asymmetry
Arashiki N, et al.
Biochemistry, 55(25), 3504-3504 (2016)
Elena Zaitseva et al.
Cell host & microbe, 22(1), 99-110 (2017-07-14)
HIV-1 entry into host cells starts with interactions between the viral envelope glycoprotein (Env) and cellular CD4 receptors and coreceptors. Previous work has suggested that efficient HIV entry also depends on intracellular signaling, but this remains controversial. Here we report
Measuring translocation of fluorescent lipid derivatives across yeast Golgi membranes
Natarajan P, et al.
Methods, 39(2), 163-168 (2006)
Paramasivam Natarajan et al.
Methods (San Diego, Calif.), 39(2), 163-168 (2006-07-11)
Phospholipid asymmetry is a fundamental feature of the plasma membrane of most eukaryotic cells and its regulation is linked to diverse physiological processes such as apoptosis and blood clotting [P. Williamson, R.A. Schlegel, Biochim. Biophys. Acta 1585 (2002) 53-63; R.F.
Osmotic stress adaptation in Lactobacillus casei BL23 leads tostructural changes in the cell wall polymer lipoteichoic acid
Palomino MM, et al.
Microbiology, 159(11), 2416-2426 (2013)
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