910015

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

≥95%

• Synonyme(s) : Azido-PEG₅-CH₂CO₂H, Azido-PEG₅-acid, N₃-PEG₅-CH₂COOH
• Formule empirique (notation de Hill): C₁₂H₂₃N₃O₇
• Numéro CAS: 217180-81-9
• Poids moléculaire : 321.33
• Numéro MDL: MFCD31561141
• Code UNSPSC : 12352106

Propriétés

• Pureté: ≥95%
• Forme: (Liquid or Semi-solid or Paste or Solid)
• Capacité de réaction: reaction type: click chemistry
• Pertinence de la réaction: reagent type: cross-linking reagent
• Groupe fonctionnel: azide; carboxylic acid
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O

Description

Application

This heterobifunctional, PEGylated crosslinker 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG₅-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Autres remarques

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable