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900889

Sigma-Aldrich

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate

≥95%

Synonyme(s) :

LAP

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About This Item

Formule empirique (notation de Hill):
C16H16LiO3P
Numéro CAS:
Poids moléculaire :
294.21
Code UNSPSC :
12352128
Nomenclature NACRES :
NA.23

Niveau de qualité

Pureté

≥95%

Forme

crystalline powder

Couleur

white to off-white

Température de stockage

2-8°C

Chaîne SMILES 

CC1=C(C(P(C2=CC=CC=C2)(O[Li])=O)=O)C(C)=CC(C)=C1

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Application

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) is a water soluble, cytocompatible, Type I photoinitiator for use in the polymerization of hydrogels or other polymeric materials. This photoinitator is preferred over Irgacure 2959 for biological applications due to its increased water solubility, increased polymerization rates with 365 nm light, and absorbance at 400 nm allowing for polymerization with visible light. The improved polymerization kinetics enable cell encapsualation at reduced initiator concentration and longer wavelength light, which has been shown to reduce initiator toxicity and increase cell viability.

Caractéristiques et avantages

  • Superior water solubility
  • Biocompatible
  • Sensitiveto visible light

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Joshua D McCall et al.
Biomacromolecules, 13(8), 2410-2417 (2012-06-30)
Photoinitiated polymerization remains a robust method for fabrication of hydrogels, as these reactions allow facile spatial and temporal control of gelation and high compatibility for encapsulation of cells and biologics. The chain-growth reaction of macromolecular monomers, such as acrylated PEG
Kavin Kowsari et al.
iScience, 24(11), 103372-103372 (2021-11-27)
To address current unmet needs in terms of scalability and material biocompatibility for future photocrosslinking-based additive manufacturing technologies, emergent platform designs are in inexorable demand. In particular, a shift from the present use of cell-damaging UV light sources in light-based
Andrew C Daly et al.
Nature communications, 12(1), 753-753 (2021-02-04)
Cellular models are needed to study human development and disease in vitro, and to screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of functional tissue models with requisite cell densities and heterogeneity to appropriately model
Zhiguang Qiao et al.
Biomaterials, 266, 120385-120385 (2020-10-30)
Despite significant advances in osteochondral tissue engineering, it remains challenging to successfully reconstruct native-like complex tissues organized in three-dimension with spatially varying compositional, structural and functional properties. In this contribution, inspired by the gradients in extracellular matrix (ECM) composition and
Benjamin D Fairbanks et al.
Macromolecules, 44(8), 2444-2450 (2011-04-23)
Various techniques have been adopted to impart a biological responsiveness to synthetic hydrogels for the delivery of therapeutic agents as well as the study and manipulation of biological processes and tissue development. Such techniques and materials include polyelectrolyte gels that

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Contenu apparenté

Tissue engineering fabricates tissues cultures from scaffolds, living cells, and biologically active molecules by simulating the microenvironment of the body to repair or replace damaged tissue.

Tissue engineering fabricates tissues cultures from scaffolds, living cells, and biologically active molecules by simulating the microenvironment of the body to repair or replace damaged tissue.

L'ingénierie tissulaire permet de fabriquer des cultures de tissus à partir de supports, de cellules vivantes et de molécules biologiquement actives en simulant le microenvironnement de l'organisme pour réparer ou remplacer un tissu endommagé.

L'ingénierie tissulaire permet de fabriquer des cultures de tissus à partir de supports, de cellules vivantes et de molécules biologiquement actives en simulant le microenvironnement de l'organisme pour réparer ou remplacer un tissu endommagé.

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