764191

Alkyne-PEG5-N-hydroxysuccinimidyl ester

• Synonyme(s) : Acetylene-PEG5-NHS ester, Alkyne-PEG5-NHS ester, Alkyne-PEG5-succinimidyl ester
• Formule empirique (notation de Hill): C₁₈H₂₇NO₉
• Poids moléculaire : 401.41
• Numéro MDL: MFCD22574798
• Code UNSPSC : 12352108
• ID de substance PubChem : 329767105
• Nomenclature NACRES : NA.22

Propriétés

• Forme: liquid
• Niveau de qualité: 100
• Capacité de réaction: reaction type: click chemistry
• Pertinence de la réaction: reagent type: cross-linking reagent
• Groupe fonctionnel: NHS ester; alkyne
• Température de stockage: −20°C
• Chaîne SMILES: C#CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
• InChI: 1S/C18H27NO9/c1-2-6-23-8-10-25-12-14-27-15-13-26-11-9-24-7-5-18(22)28-19-16(20)3-4-17(19)21/h1H,3-15H2
• Clé InChI: ACZDUKRWTPZVRP-UHFFFAOYSA-N

Description

Application

Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a primary amine. The succinimidyl ester group will react preferentially with primary amines to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification amine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable