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702153

Sigma-Aldrich

Hydroxyapatite

nanoparticles, dispersion, 10 wt. % in H2O, <200 nm particle size (BET)

Synonyme(s) :

Calcium hydroxide phosphate, Calcium hydroxylapatite, Calcium hydroxyphosphate, Nano hydroxyapatatite, Pentacalcium hydroxide triphosphate

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About This Item

Formule linéaire :
[Ca5(OH)(PO4)3]x
Numéro CAS:
Poids moléculaire :
502.31
Numéro MDL:
Code UNSPSC :
12352302
ID de substance PubChem :
Nomenclature NACRES :
NA.23

Forme

dispersion
nanoparticles

Niveau de qualité

Contient

≤0.025 wt. % dispersant (non-metal based)

Concentration

10 wt. % in H2O

Superficie

14.3 m2/g , typical

Taille des particules

<200 nm (BET)

pH

4-6

Densité

1.038 g/mL at 25 °C

Chaîne SMILES 

[Ca++].[Ca++].[Ca++].[Ca++].O[Ca+].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O

InChI

1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

Clé InChI

XYJRXVWERLGGKC-UHFFFAOYSA-D

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Description générale

Hydroxyapatite(HAP) is an osteoconductive bioceramic material which has uniqueability to form direct bonds with living tissues. It can be easily prepared byvarious techniques such as sol-gel, hydrothermal, multiple emulsion, biomimeticdeposition, and electrodeposition.

Application

Hydroxyapatite can be used as:
  • An implant material for bone substitute due to its chemical similarity to the inorganic component of bone and osteo inductive properties.
  • A vehicle for gene and drug delivery because of its encapsulation capacity and affinity to several drugs and proteins.
  • A pH responsive particulate emulsifier.

Caractéristiques et avantages

  • Biocompatible
  • Osteoconductive
  • Stable under physiological conditions
  • High mechanical strength

Informations légales

Product of Engi-Mat Co.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Martin P Reichhardt et al.
Life science alliance, 3(4) (2020-02-27)
The scavenger receptor cysteine-rich (SRCR) family of proteins comprises more than 20 membrane-associated and secreted molecules. Characterised by the presence of one or more copies of the ∼110 amino-acid SRCR domain, this class of proteins have widespread functions as antimicrobial
Xi Chen et al.
The Journal of biological chemistry, 289(16), 11162-11174 (2014-03-13)
Calcium phosphate precipitates (CPPs) form complexes with DNA, which enter cells via endocytosis. Under this condition CPPs induce autophagy via the canonic autophagy machinery. Here we showed that CPP-induced autophagy was also dependent on endocytosis as the process was significantly
Tie Liu et al.
Bone, 56(1), 110-118 (2013-06-05)
As an alternative to an autologous bone graft, deproteinized bovine bone (DBB) is widely used in the clinical dentistry. Although DBB provides an osteoconductive scaffold, it is not capable of enhancing bone regeneration because it is not osteoinductive. In order
Ehud Segal et al.
PloS one, 4(4), e5233-e5233 (2009-04-22)
There is an immense clinical need for novel therapeutics for the treatment of angiogenesis-dependent calcified neoplasms such as osteosarcomas and bone metastases. We developed a new therapeutic strategy to target bone metastases and calcified neoplasms using combined polymer-bound angiogenesis inhibitors.
Layal Safa et al.
Biochimie, 103, 80-88 (2014-04-22)
Replication protein A (RPA) is a single-stranded DNA binding protein that plays an essential role in telomere maintenance. RPA binds to and unfolds G-quadruplex (G4) structures formed in telomeric DNA, thus facilitating lagging strand DNA replication and telomerase activity. To

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