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X4879

Sigma-Aldrich

Xaliproden

≥97% (HPLC), solid

Synonyme(s) :

1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride, SR-57746A

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About This Item

Formule empirique (notation de Hill):
C24H22F3N · HCl
Numéro CAS:
90494-79-4
Poids moléculaire :
417.89
Numéro MDL:
MFCD00896209
Code UNSPSC :
12352200
ID de substance PubChem :
329830807
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Essai

≥97% (HPLC)

Forme

solid

Couleur

white to off-white

Solubilité

DMSO: ≥5 mg/mL

Auteur

Sanofi Aventis

Température de stockage

2-8°C

Chaîne SMILES 

Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2

InChI

1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H

Clé InChI

WVHBEIJGAINUBW-UHFFFAOYSA-N

Informations sur le gène

human ... HTR1A(3350)

Actions biochimiques/physiologiques

5-HT1A serotonin receptor agonist; neuroprotectant

Caractéristiques et avantages

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
029K4605V
029K4605
028K46081
028K4608

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

M Magazin et al.
Brain research. Molecular brain research, 53(1-2), 301-306 (1998-04-29)
Rapid neurite retraction and transient rounding of serum-starved NG108-15 and PC12 cells by lysophosphatidic acid (LPA) is retarded and reduced by pre-incubation of the cells with the small non-peptidic molecule, SR 57746A, which exhibits neurotrophic properties. The compound also antagonizes
P Murali Doraiswamy et al.
Expert opinion on pharmacotherapy, 7(1), 1-10 (2005-12-24)
This review examines key pharmacological strategies that have been clinically studied for the primary or secondary prevention of Alzheimer's disease. Much information (neuropsychological, genetic and imaging) is already available to characterise an individual's risk for developing Alzheimer's disease. However, regulatory
Sherry Wolf et al.
European journal of cancer (Oxford, England : 1990), 44(11), 1507-1515 (2008-06-24)
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side effect of many commonly used chemotherapeutic agents, including platinum drugs, taxanes, epothilones and vinca alkaloids, and also newer agents such as bortezomib and lenolidamide. Symptom control studies have been conducted
J P Terranova et al.
Neuroscience letters, 213(2), 79-82 (1996-08-02)
Different putative toxic amyloid beta (A beta) peptides, beta (1-42), beta (1-40) and beta (25-35), were infused (0.75, 1.5 or 3 nmol) in the rat medial septum. Memory deficits were then investigated using the social recognition test. A significant amnesia
A Appert-Collin et al.
International journal of immunopathology and pharmacology, 17(2), 157-164 (2004-06-03)
Compounds possessing neurotrophic properties may represent a possible treatment for neurodegenerative disorders such as amyotrophic lateral sclerosis. Xaliproden (SR57746A), an orally-active non-peptide compound, which has been found to exhibit neurotrophic effects in vitro and in vivo, increased the lifespan and
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