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Principaux documents

SML1489

Sigma-Aldrich

FICZ

≥95% (HPLC), lyophilized powder, AhR agonist

Synonyme(s) :

5,11-Dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde, 6-Formylindolo[3,2-b]carbazole

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About This Item

Formule empirique (notation de Hill):
C19H12N2O
Numéro CAS:
172922-91-7
Poids moléculaire :
284.31
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Nom du produit

FICZ, ≥95% (HPLC)

Niveau de qualité

100

Essai

≥95% (HPLC)

Forme

lyophilized powder

Couleur

yellow

Solubilité

DMSO: 0.5 mg/mL, clear (warmed)

Température de stockage

−20°C

Chaîne SMILES 

[nH]1c2c(c5c1cccc5)cc3[nH]c4c(c3c2C=O)cccc4

InChI

1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H

Clé InChI

ZUDXFBWDXVNRKF-UHFFFAOYSA-N

Actions biochimiques/physiologiques

FICZ (6-formylindolo(3,2b)carbazole) being a photooxidation product of tryptophan, might serve as a chemical messenger of light.
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR).

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000191076
0000191075
0000161966
0000158498
0000158499

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