The product is not assigned an expiration date. In the original sealed container it is quite stable. A warranty of 1 year from the date of shipment applies. It should be stored at −20°C in the powdered format. Following reconstitution in DMSO at 0.5 mg/mL, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
SML1094
CHIR 98014
≥98% (HPLC), powder, GSK-3 inhibitor
Synonyme(s) :
N-6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine, CHIR-98014
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Formule empirique (notation de Hill):
C20H17Cl2N9O2
Numéro CAS:
Poids moléculaire :
486.31
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Nom du produit
CHIR 98014, ≥98% (HPLC)
Niveau de qualité
Essai
≥98% (HPLC)
Forme
powder
Couleur
white to brown
Solubilité
DMSO: 0.5 mg/mL, clear (warmed)
Température de stockage
−20°C
Chaîne SMILES
NC1=C(C=CC(NCCNC2=NC(C3=C(Cl)C=C(Cl)C=C3)=C(N4C=CN=C4)C=N2)=N1)[N+]([O-])=O
InChI
1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29)
Clé InChI
MDZCSIDIPDZWKL-UHFFFAOYSA-N
Application
CHIR 98014 has been used for the generation of small molecules neural progenitor cells and differentiation towards motor neurons.[1] It has also been used as a Wnt/β-catenin pharmacological agonist in the cell-conditioned medium to perform chromatin immunoprecipitation (ChIP) studies in HT22 neurons.[2]
Actions biochimiques/physiologiques
CHIR 98014 is a glycogen synthase kinase-3 (GSK-3) inhibitor with IC50 values of 0.65 nM and 0.58 nM for GSK3α and GSK3β, respectively. CHIR98014 is 500-fold to >10,000-fold selectivity for GSK-3 versus 20 other protein kinases tested, including closest homologs Cdc2 and ERK2.
CHIR 98014 is a glycogen synthase kinase-3 (GSK-3) inhibitor.
Reconstitution
Reconstitute in DMSO at 0.5 mg/mL. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Stockage et stabilité
The product in the original sealed container is quite stable. It should be stored at −20°C in the powdered format.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Faites votre choix parmi les versions les plus récentes :
Certificats d'analyse (COA)
Lot/Batch Number
Vous ne trouvez pas la bonne version ?
Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Les clients ont également consulté
Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells.
Diana Gumber et al.
eLife, 9 (2020-12-18)
WNT proteins are secreted symmetry breaking signals that interact with cell surface receptors of the FZD family to regulate a multitude of developmental processes. Studying selectivity between WNTs and FZDs has been hampered by the paucity of purified WNT proteins
Matías A Medina et al.
Translational psychiatry, 8(1), 45-45 (2018-03-06)
Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated mutations disrupt hippocampal and cortical function. Here we show
Paola Rusmini et al.
Autophagy, 15(4), 631-651 (2018-10-20)
Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be beneficial in neurodegenerative diseases (NDs). The natural compound trehalose promotes autophagy via TFEB (transcription factor EB), ameliorating disease phenotype in multiple ND
-
What are the storage conditions and expiry for this product in its original form and once reconstituted? Material: CHIR-98014 SML1094-25MG
1 answer-
Helpful?
-
Active Filters
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique
