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Key Documents

SML0885

Sigma-Aldrich

bpV(pic)

≥95% V basis

Synonyme(s) :

Dipotassium Bisperoxovanadium(pic) dihydrate, Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate, K2 [VO(O2)2C6H4NO2] · 2 H2O

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About This Item

Formule empirique (notation de Hill):
K2VOO2O2C6H4NO2 · 2H2O
Numéro CAS:
148556-27-8
Poids moléculaire :
367.27
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥95% V basis

Forme

powder

Conditions de stockage

protect from light

Couleur

faintly yellow to dark yellow

Solubilité

H2O: 20 mg/mL, clear

Température de stockage

−20°C

Application

bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.

Actions biochimiques/physiologiques

bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).

Autres remarques

Light Sensitive

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

Xiaodong Wu et al.
CNS neuroscience & therapeutics, 29(11), 3598-3611 (2023-06-13)
Neuronal abnormalities are closely associated with major depressive disorder (MDD). Available evidence suggests a role for microRNAs (miRNAs) in regulating the expression of genes involved in MDD. Hence, miRNAs that can be potential therapeutic targets need to be identified. A
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair.
Lai J P, et al.
British Journal of Pharmacology, 152(8), 1172-1184 (2007)
Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription.
Azebi S, et al.
bioRxiv, 284695 (2018)
Qian Chen et al.
Journal of inflammation research, 15, 2707-2720 (2022-05-04)
This study aims to investigate the cytoprotective and anti-inflammatory effects of an α2-adrenoreceptor (α2-AR) agonist, dexmedetomidine (Dex), on lipopolysaccharides (LPS)-induced acute lung injury and underlying mechanisms with focus on alveolar macrophage polarization modulation. C57BL/6 mice were intraperitoneally injected LPS (10
Ali A Shati et al.
Clinical and experimental pharmacology & physiology, 49(2), 275-290 (2021-09-28)
This study evaluated the protective effect of resolvin D1 (RVD1) against cadmium chloride (CdCl2 )-induced hippocampal damage and memory loss in rats and investigated if such protection is mediated by modulating the PTEN/PI3K/Akt/mTOR pathway. Adult male Wistar rats (n =
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