SAB5700286

Anti-Phospho-CHEK1-S280 antibody produced in rabbit

• Synonyme(s) : CHEK1, CHK1
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: 43; 50; 54
• Espèces réactives: mouse, human, rat
• Concentration: 1.66 mg/ml
• Technique(s): immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200; western blot: 1:200-1:2000
• Numéro d'accès UniProt: O14757
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pSer280)
• Informations sur le gène: human ... CHEK1(1111)

Description

Description générale

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Immunogène

A synthetic phosphorylated peptide around S280 of human CHEK1 (NP_001265.2).

Forme physique

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Stockage et stabilité

Store at -20℃. Avoid freeze / thaw cycles.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable