M1275

Naproxen sodium

98.0-102.0%

• Synonyme(s) : (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt
• Formule empirique (notation de Hill): C₁₄H₁₃NaO₃
• Numéro CAS: 26159-34-2
• Poids moléculaire : 252.24
• Numéro CE : 247-486-2
• Numéro MDL: MFCD00058507
• Code UNSPSC : 12352200
• ID de substance PubChem : 57654352
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Pureté: 98.0-102.0%
• Forme: powder
• Solubilité: water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Auteur: Bayer
• Chaîne SMILES: [Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
• InChI: 1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
• Clé InChI: CDBRNDSHEYLDJV-FVGYRXGTSA-M
• Informations sur le gène: human ... PTGS1(5742) , PTGS2(5743)

Description

Description générale

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

Application

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.

Actions biochimiques/physiologiques

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

Caractéristiques et avantages

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H360
• Conseils de prudence: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classification des risques: Acute Tox. 4 Oral - Repr. 1A
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves