H7250

Histamine dihydrochloride

≥99% (TLC), powder, endogenous histamine receptor agonist

• Synonyme(s) : 2-(4-Imidazolyl)ethylamine dihydrochloride
• Formule empirique (notation de Hill): C₅H₉N₃ · 2HCl
• Numéro CAS: 56-92-8
• Poids moléculaire : 184.07
• Numéro Beilstein : 3624116
• Numéro CE : 200-298-4
• Numéro MDL: MFCD00012703
• Code UNSPSC : 12352116
• eCl@ss : 32160406
• ID de substance PubChem : 24277777
• Nomenclature NACRES : NA.77

Propriétés

• product name: Histamine dihydrochloride, ≥99% (TLC), powder
• Pureté: ≥99% (TLC)
• Forme: powder
• Couleur: white to off-white
• Pf: 249-252 °C (lit.)
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl[H].Cl[H].NCCc1c[nH]cn1
• InChI: 1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
• Clé InChI: PPZMYIBUHIPZOS-UHFFFAOYSA-N
• Informations sur le gène: human ... HRH1(3269) , HRH2(3274)

Description

Description générale

Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients.

Application

Histamine dihydrochloride has been used:

• as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
• to determine its level in fish using HPLC (high performance liquid chromatography)
• to assess the tracheal response to antigens in guinea-pigs

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H315,H317,H319,H334,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves