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G2879

Sigma-Aldrich

Glycine hydrochloride

≥99% (HPLC)

Synonyme(s) :

Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Formule linéaire :
H2NCH2CO2H · HCl
Numéro CAS:
6000-43-7
Poids moléculaire :
111.53
Numéro CE :
227-841-8
Numéro MDL:
MFCD00012872
Code UNSPSC :
12352209
eCl@ss :
32160406
ID de substance PubChem :
24895108
Nomenclature NACRES :
NA.32

Pureté

≥99% (HPLC)

Forme

powder

Poids mol.

111.53

Conditions de stockage

(Tightly closed Dry)

Concentration

≤100%

Technique(s)

immunohistochemistry: suitable

Pf

176-180 °C (lit.)

Solubilité

water: 0.5 g/mL, clear, colorless

Température de stockage

room temp

Chaîne SMILES 

Cl.NCC(O)=O

InChI

1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H

Clé InChI

IVLXQGJVBGMLRR-UHFFFAOYSA-N

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Description générale

Research area: Neuroscience

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.
Glycine hydrochloride has been used:
  • in the preparation of glycine-HCl buffer
  • to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
  • to regenerate the sensor to elute the bound C-reactive protein (CRP)

Actions biochimiques/physiologiques

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.
Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

299294

Glycine-15N, 98 atom % 15N

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Danger

Mentions de danger

H314

Classification des risques

Eye Dam. 1 - Skin Corr. 1

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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A comparative study on the chitosan membranes prepared from glycine hydrochloride and acetic acid
Ma B, et al.
Carbohydrate Polymers, 91(2), 477-482 (2013)
Hydrolysis of organic phosphates by commercially available phytases: Biocatalytic potentials and effects of ions on their enzymatic activities
Tazisong IA, et al.
Journal of food, agriculture & environment, 6(3&4), 500-505 (2008)
M D Wheeler et al.
Cellular and molecular life sciences : CMLS, 56(9-10), 843-856 (2001-02-24)
The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes.
Glycine
Hall JC
JPEN. Journal of parenteral and enteral nutrition, 22(6), 393-398 (2019)
Zipei Feng et al.
Journal of immunology (Baltimore, Md. : 1950), 196(9), 3943-3950 (2016-03-20)
Recent advances in multiplex immunohistochemistry techniques allow for quantitative, spatial identification of multiple immune parameters for enhanced diagnostic and prognostic insight. However, applying such techniques to murine fixed tissues, particularly sensitive epitopes, such as CD4, CD8α, and CD19, has been
Afficher tous les articles scientifiques apparentés

Protocoles

Stripping and Reprobing Western Blotting Membranes

This page shows and discusses three protocols for stripping and reprobing a western blot membrane.

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