E101

S-(−)-Eticlopride hydrochloride

≥98% (HPLC), powder

• Synonyme(s) : FLB 131, S-(−)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride
• Formule empirique (notation de Hill): C₁₇H₂₅ClN₂O₃ · HCl
• Numéro CAS: 97612-24-3
• Poids moléculaire : 377.31
• Numéro MDL: MFCD00055132
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278428
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]27/D −7.2°, c = 0.3 in methanol(lit.)
• Conditions de stockage: desiccated
• Couleur: off-white
• Solubilité: H₂O: soluble >10 mg/mL; ethanol: soluble 2.6 mg/mL; 0.1 M HCl: soluble 7 mg/mL
• Chaîne SMILES: Cl.CCN1CCC[C@H]1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC
• InChI: 1S/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2;/h9,12,21H,4-8,10H2,1-3H3,(H,19,22);1H/t12-;/m0./s1
• Clé InChI: HFJFXXDHVWLIKX-YDALLXLXSA-N
• Informations sur le gène: human ... DRD2(1813)

Description

Application

S-(−)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.

Actions biochimiques/physiologiques

Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2 receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.

Notes préparatoires

Solutions may be stored at 4° C for several days

Informations légales

Manufactured and sold with the permission of Astra AB.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)