The concentration is expressed as weight/volume (w/v). The exact concentration is provided on the lot-specific certificate of analysis (COA).
C9394
Chlorhexidine digluconate solution
20% in H2O
Synonyme(s) :
1,6-Bis(N5-[p-chlorophényl]-N1-biguanido)hexane ; 1,1′-Hexaméthylène bis(5 -p-chlorophényl] biguanide)
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A propos de cet article
Numéro CAS:
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
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liquid
Quality Segment
concentration
20% in H2O
solubility
water: soluble 50 % (w/v)
density
1.06 g/mL at 25 °C (lit.)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
InChI
1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1
InChI key
YZIYKJHYYHPJIB-UUPCJSQJSA-N
Application
Chlorhexidine has been used to study how essential oils improve skin antisepsis when combined with chlorhexidine digluconate and is used for skin permeation studies . Chronic rinsing with chlorhexidine has been shown to decrease the saltiness of NaCl and the bitterness of quinine.
Used to study mechanism of membrane dysruption by bis(biguanide) molecules.
Biochem/physiol Actions
Agent antimicrobien cationique à large spectre appartenant à la famille des bis(guanides). Son mode d′action consiste à déstabiliser la membrane externe des bactéries. Il est principalement utilisé comme antiseptique/désinfectant topique pour la cicatrisation des plaies, diverses applications dentaires et le brossage chirurgical.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Light sensitive.
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Cet article | |||
|---|---|---|---|
| description 20% in H2O | description Pharmaceutical Secondary Standard; Certified Reference Material | description ≥98% | description European Pharmacopoeia (EP) Reference Standard |
| mode of action cell membrane | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 300 | Quality Level 100 | Quality Level - |
| form liquid | form - | form powder | form - |
| solubility water: soluble 50 % (w/v) | solubility - | solubility - | solubility - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
Mot-clé
Danger
Codes de danger
Mentions de précaution
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
Classe de stockage
12 - Non Combustible Liquids
Que se passe-t-il ?
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
EPI (équipement de protection individuelle)
Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)
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Is the 20% chlorhexidine digluconate (C9394) calculated as weight/weight (w/w) or weight/volume (w/v)? Because the specific gravity is given as 1.06 g/mL, this matters for calculating the molar concentration.
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Hi, Is this pharma grade ? Kidn regards Archana
1 answer-
No, this product is not pharmaceutical grade. It is intended for research use only. Currently, a pharmaceutical grade of this material is not available.
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