This product has not been tested for in vivo use. The material is soluble at 50 mg/mL in 1N HCl. The stock solution would require sterile filtration before further dilution with a sterile buffer or medium.
C6506
4-Chloro-DL-phenylalanine
Synonyme(s) :
PCP, PCPA
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Formule linéaire :
ClC6H4CH2CH(NH2)CO2H
Numéro CAS:
Poids moléculaire :
199.63
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352209
ID de substance PubChem :
Nomenclature NACRES :
NA.32
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Forme
solid
Niveau de qualité
Score du produit alternatif plus écologique
old score: 2
new score: 1
Find out more about DOZN™ Scoring
Caractéristiques du produit alternatif plus écologique
Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
Pf
>240 °C (dec.) (lit.)
Autre catégorie plus écologique
Température de stockage
room temp
Chaîne SMILES
NC(Cc1ccc(Cl)cc1)C(O)=O
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
Clé InChI
NIGWMJHCCYYCSF-UHFFFAOYSA-N
Informations sur le gène
human ... TPH1(7166) , TPH2(121278)
Vous recherchez des produits similaires ? Visite Guide de comparaison des produits
Catégories apparentées
Description générale
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.
Application
4-Chloro-DL-phenylalanine has been used:
- as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish[1]
- to induce insomnia in rat models[2]
- used to treat embryos to examine its effect on serotonin[3]
- for the selection of Enterococcus faecalis transformants with pESentA32 plasmid[4]
- to feed flies to explore serotonin effect[5]
Actions biochimiques/physiologiques
4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.[6]
Tryptophan hydroxylase inhibitor.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 3 Oral - Skin Sens. 1
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Faites votre choix parmi les versions les plus récentes :
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Les clients ont également consulté
Frederic D L Leusch et al.
Chemosphere, 191, 868-875 (2017-11-07)
Environmental chemicals can induce thyroid disruption through a number of mechanisms including altered thyroid hormone biosynthesis and transport, as well as activation and inhibition of the thyroid receptor. In the current study six in vitro bioassays indicative of different mechanisms of
Hadas Tsivion-Visbord et al.
Translational psychiatry, 10(1), 305-305 (2020-09-03)
Schizophrenia is a debilitating psychiatric disorder with a significant number of patients not adequately responding to treatment. Phencyclidine (PCP) is used as a validated model for schizophrenia, shown to reliably induce positive, negative and cognitive-like behaviors in rodents. It was
Mustafa Alshawaqfeh et al.
Biology direct, 12(1), 4-4 (2017-02-02)
Recent developments of high throughput sequencing technologies allow the characterization of the microbial communities inhabiting our world. Various metagenomic studies have suggested using microbial taxa as potential biomarkers for certain diseases. In practice, the number of available samples varies from
PCPA protects against monocrotaline-induced pulmonary arterial remodeling in rats: potential roles of connective tissue growth factor
Bai Y, et al.
Testing, 8(67), 111642-111642 (2017)
Serotonin activated hepatic stellate cells contribute to sex disparity in hepatocellular carcinoma
Yang Q, et al.
Cellular and molecular gastroenterology and hepatology, 3(3), 484-499 (2017)
Chromatograms
application for HPLC-
For in vivo experiment, does this have to be dissolved in 1N HCL?
1 answer-
Helpful?
-
Active Filters
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique
