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C4780

Sigma-Aldrich

Coenzyme A sodium salt hydrate

BioReagent, suitable for cell culture

Synonyme(s) :

CoA Na2

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About This Item

Formule empirique (notation de Hill):
C21H36N7O16P3S · xNa+ · yH2O
Numéro CAS:
55672-92-9
Poids moléculaire :
767.53 (anhydrous free acid basis)
Numéro CE :
259-747-8
Code UNSPSC :
12352205
ID de substance PubChem :
24892723
Nomenclature NACRES :
NA.75

Source biologique

yeast

Description

cofactor for acyl transfer

Gamme de produits

BioReagent

Pureté

≥85% (HPLC)

Forme

powder

Technique(s)

cell culture | mammalian: suitable

Solubilité

water: 50 mg/mL, clear, colorless to faintly yellow

Température de stockage

−20°C

Chaîne SMILES 

[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS

Clé InChI

SYTRWOCXZXQBPW-CLVRNSBASA-M

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Application

Coenzyme A sodium salt hydrate has been used:
  • in the branch chain aminotransferase enzymatic assay and protein determination
  • in the assay for halogenation of pyrrolyl-S-Bmp1 (an acyl carrier protein (ACP)-thioesterase (TE) di-domain protein) by Bmp2
  • as an extracellular coenzyme A (CoA) in in vitro and in vivo experiments to study alternative routes by which cells and organisms can obtain CoA

Actions biochimiques/physiologiques

Coenzyme A (CoA) is a ubiquitous cofactor that plays an important role in many metabolic pathways, mainly as acyl-CoA. It is essential for the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. CoA facilitates acyl group transfers, especially in fatty acid and lipid metabolism reactions. It is associated with neurodegeneration, autophagy, protein acetylation, and signal transduction.

Qualité

Enzymatically assayed using phosphotransacetylase. Approx. 95% CoA-SH

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Balaji Srinivasan et al.
Nature chemical biology, 11(10), 784-792 (2015-09-01)
The metabolic cofactor coenzyme A (CoA) gained renewed attention because of its roles in neurodegeneration, protein acetylation, autophagy and signal transduction. The long-standing dogma is that eukaryotic cells obtain CoA exclusively via the uptake of extracellular precursors, especially vitamin B5
Yongzhong Wei et al.
World journal of gastroenterology, 14(2), 193-199 (2008-01-12)
Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD
Yao Rong et al.
eLife, 10 (2021-08-20)
TMEM120A, a member of the transmembrane protein 120 (TMEM120) family, has a pivotal function in adipocyte differentiation and metabolism, and may also contribute to sensing mechanical pain by functioning as an ion channel named TACAN. Here we report that expression
Le Tran Phuc Khoa et al.
Cell stem cell, 27(3), 441-458 (2020-07-02)
Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process
Krista Yang et al.
STAR protocols, 2(3), 100687-100687 (2021-08-18)
Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria freshly isolated from tissue, along with examples to assess the potency and specificity

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