C3019

Coenzyme A trilithium salt

≥93%

• Synonyme(s) : CoA Li₃
• Formule empirique (notation de Hill): C₂₁H₃₃Li₃N₇O₁₆P₃S
• Numéro CAS: 18439-24-2
• Poids moléculaire : 785.33
• Numéro CE : 242-317-9
• Numéro MDL: MFCD00075848
• Code UNSPSC : 41106305
• ID de substance PubChem : 24892557
• Nomenclature NACRES : NA.51

Propriétés

• Pureté: ≥93%
• Forme: powder
• Température de stockage: −20°C
• Chaîne SMILES: [Li+].[Li+].[Li+].CC(C)(COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI: 1S/C21H36N7O16P3S.3Li/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;/q;3*+1/p-3/t11-,14-,15-,16?,20-;;;/m1.../s1
• Clé InChI: QSCBPHBAFBVXRK-HJKJOZROSA-K

Description

Description générale

Coenzyme A (CoA) is synthesized from phosphopantothenate by the action of enzyme pantothenate kinase and is the master regulator.

Application

Coenzyme A trilithium salt has been used:

• in standard curve generation in the kinetic assay of acetyltransferase Gcn5 acylation
• as a cofactor in JNADH and JNADPH production assay
• in the labeling of Alexa647 (AF647) probe

Actions biochimiques/physiologiques

Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. Acyl CoA accumulation is implicated in metabolic disorders and may indirectly lead to the pathogenesis associated with carbon-induced mitochondrial stress heart failure, diabetes and obesity.

Autres remarques

For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)