C1768

Cytarabine

≥90% (HPLC), crystalline, DNA replication inhibitor

• Synonyme(s) : (β-D-Arabinofuranosyl)cytosine, Ara-C, Arabinocytidine, Arabinosylcytosine, Cytarabine, Cytosine arabinoside
• Formule empirique (notation de Hill) : C₉H₁₃N₃O₅
• Numéro CAS: 147-94-4
• Poids moléculaire : 243.22
• NACRES: NA.77
• PubChem Substance ID: 24892435
• UNSPSC Code: 12352200
• EC Number: 205-705-9
• MDL number: MFCD00066487
• Beilstein/REAXYS Number: 89175
• Assay: ≥90% (HPLC)
• Form: crystalline

Propriétés

• Nom du produit: Cytosine β-D-arabinofuranoside, crystalline, ≥90% (HPLC)
• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: crystalline
• storage temp.: 2-8°C
• SMILES string: NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
• InChI: 1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
• InChI key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
• Gene Information: human ... POLA1(5422), POLA2(23649), POLB(5423), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558) ; mouse ... Cda(72269)

Description

Biochem/physiol Actions

Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.

Features and Benefits

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Informations sur la sécurité

• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
• pictograms: GHS08
• signalword: Danger
• hcodes: H340,H361fd
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 1B - Repr. 2
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects