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B4186

Sigma-Aldrich

Butyrylcholinesterase human

vial of ≥4 units

Synonyme(s) :

Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase

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About This Item

Numéro CAS:
9001-08-5
Numéro de classification (Commission des enzymes):
3.1.1.8 (BRENDA, IUBMB)
Numéro CE :
232-579-2
Numéro MDL:
MFCD00081455
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Forme

powder

Niveau de qualité

200

Activité spécifique

≥50 units/mg protein

Conditionnement

vial of ≥4 units

Numéro d'accès UniProt

P06276

Température de stockage

2-8°C

Informations sur le gène

human ... BCHE(590)

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Application

BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds [1].
Butyrylcholinesterase human has been used to study its role as a modulator of pathological features of Alzheimer′s disease (AD) in vivo.[2]

Actions biochimiques/physiologiques

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates.
Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities[3]. It is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates.[4] BChE hydrolyzes large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates.[5] BchE may be used to treat organophosphate toxicity. It is a critical target for Alzheimer′s disease (AD) therapy.[6]

Définition de l'unité

One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.

Remarque sur l'analyse

Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surfaceantigen, and Hepatitis C antibodies.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H334

Conseils de prudence

P261 - P284 - P501

Classification des risques

Resp. Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000323841
0000370239
0000336411
0000336411
0000370239

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Consulter la Bibliothèque de documents

The key role of butyrylcholinesterase during neurogenesis and neural disorders: an antisense-5? butyrylcholinesterase-DNA study
Mack A and Robitzki A
Progress in Neurobiology, 60(6), 607-628 (2000)
Butyrylcholinesterase: an important new target in Alzheimer's disease therapy
Greig NH, et al.
International Psychogeriatrics / IPA, 14(S1), 77-91 (2002)
Cholinesterases and engineered mutants for the detection of organophosphorus pesticide residues
Xu YL, et al.
Sensors, 18(12), 4281-4281 (2018)
The apolipoprotein E varepsilon4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase
Darreh-Shori T, et al.
Neurobiology of Aging, 32(7), 1236-1248 (2011)
Neurobiology of butyrylcholinesterase.
Sultan Darvesh et al.
Nature reviews. Neuroscience, 4(2), 131-138 (2003-02-04)
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Questions

1–4 of 4 Questions  

  1. How should Product B4186, Butyrylcholinesterase from human serum, be reconstituted?

    1 answer

    1. The enzyme can be reconstituted in 20 mM sodium phosphate buffer, pH 7.0, with 0.15 M sodium chloride.

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  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. Are any buffer salts present in Product B4186, Butyrylcholinesterase from human serum?

    1 answer

    1. This product was lyophilized from 20 mM ammonium bicarbonate, which is a volatile buffer. So it would be expected to contain only traces of buffer salts.

      Helpful?

  4. What amount of enzyme is present in 1 vial of Product B4186, Butyrylcholinesterase from human serum?

    1 answer

    1. Each vial will contain at least 5 units. The vial content is given on the certificate of analysis of each lot. The vial may be substantially overpacked.

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