A8452

Monoclonal Anti-α-Fetoprotein (AFP) antibody produced in mouse

ascites fluid, clone C3

• Synonyme(s) : Afp Antibody, Afp Antibody - Monoclonal Anti-α-Fetoprotein (AFP) antibody produced in mouse, Alpha Fetoprotein Antibody
• Numéro MDL: MFCD00162111
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.46

Propriétés

• Source biologique: mouse
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: ascites fluid
• Type de produit anticorps: primary antibodies
• Clone: C3, monoclonal
• Contient: 15 mM sodium azide
• Espèces réactives: pig, canine, human
• Ne doit pas réagir avec: mouse, cat, rat, bovine
• Technique(s): dot blot: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using human fetal liver; indirect ELISA: suitable
• Isotype: IgG2a
• Numéro d'accès UniProt: P02771
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... AFP(174)

Description

Description générale

α-Fetoprotein (AFP) is a one of the main glycoprotein present in the fetal liver, gastrointestinal tract, and yolk sac. AFP levels in amniotic fluid have been used as biomarkers for anencephaly and spina bifida.

Monoclonal Anti-α-Fetoprotein (AFP) (mouse IgG2a isotype) is derived from the C3 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified human α-fetoprotein.

Immunogène

human α-fetoprotein

Application

Monoclonal Anti-α-Fetoprotein (AFP) antibody produced in mouse has been used in:

• enzyme-linked immunosorbent assay (ELISA)
• dot blot
• immunocytochemistry
• immunofluorescence
• immunocytochemistry

Mouse Monoclonal Anti-α-Fetoprotein has been used for immunocytochemistry. The product can also be used for dot blot and indirect ELISA.

Actions biochimiques/physiologiques

Increased concentrations of α-fetoprotein (AFP) in serum are less common in patients with malignancies of the gastrointestinal tract and of other organ systems with massive hepatic metastases. Hence, AFP determination is useful for the diagnosis of certain germ line tumors that contain yolk sac structures (testicular and ovarian tumors), hepatocellular carcinoma (hepatoma), and some malignant tumors of the gastrointestinal tract. AFP serves as an important marker for certain genetic and embryonic defects. Routine screening of pregnancies with a risk of neural tube defects (spina bifida, anencephaly, and Down′s syndrome) may be facilitated by the monitoring of AFP levels.

Description de la cible

AFP is a plasma protein found highly expressed in the human fetus where it functions to block the transport of estradiol across the placenta.

Forme physique

The product is provided as ascites fluid with 0.1% sodium azide as a preservative.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable