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A115

Supelco

Amitriptyline metabolite, (±)-E-10-hydroxylated-

analytical standard

Synonyme(s) :

(±)-(E)-5-[3-(Dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

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About This Item

Formule empirique (notation de Hill):
C20H23NO
Numéro CAS:
64520-05-4
Poids moléculaire :
293.40
Numéro MDL:
MFCD00069200
Code UNSPSC :
41116107
ID de substance PubChem :
329770681
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

200

Forme

solid

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Couleur

white

Pf

97-99 °C

Solubilité

0.1 M HCl: soluble
H2O: insoluble
methanol: soluble

Application(s)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13

InChI

1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+

Clé InChI

GHWBJXOKAFHZAI-SFQUDFHCSA-N

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Catégories apparentées

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Actions biochimiques/physiologiques

Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

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U Breyer-Pfaff et al.
Clinical pharmacology and therapeutics, 52(4), 350-358 (1992-10-01)
In 26 hospitalized patients with depression, a combined pharmacogenetic test with dextromethorphan, a substrate of cytochrome P450IID6, and mephenytoin, the S-form of which is hydroxylated by a P450IIC isozyme, was carried out before amitriptyline therapy. Metabolites were determined in 24-hour
X Zhang
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 25(4), 196-198 (1992-08-01)
The serum concentrations of amitriptyline and its 3 metabolites--nortriptyline, 10-hydroxy-amitriptyline and 10-hydroxy-nortriptyline were determined in 18 depressive patients treated with amitriptyline for 6 weeks. The relationships between the serum concentrations and the clinical effects were statistically analyzed and showed significant
F Coudoré et al.
Fundamental & clinical pharmacology, 8(6), 525-531 (1994-01-01)
Kinetics of amitriptyline (AMI), its demethylated metabolites nortriptyline (NOR) and demethylnortriptyline (DM-NOR), and its hydroxylated metabolites, the E and Z isomers or 10-hydroxy-amitriptyline (E- and Z-10-OH-AMI) and of 10-hydroxynortriptyline (E- and Z-10-OH-NOR) were studied in plasma and brain from Swiss
D S Robinson et al.
Journal of clinical psychopharmacology, 5(2), 83-88 (1985-04-01)
As part of a double-blind clinical trial comparing phenelzine and amitriptyline in outpatients with predominantly major depressive disorder, plasma tricyclic antidepressant drug concentrations were measured in 83 amitriptyline-treated patients. In 29 of these patients, hydroxymetabolites were also assayed. Patients were
X H Zhang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 28(2), 85-91 (1993-01-01)
The demethylation and hydroxylation of amitriptyline were calculated from the ratios between the area under concentration--time curve (AUC) of amitriptyline and its three metabolites in eight healthy Chinese volunteers after a single oral dose of 100 mg amitriptyline. Great interindividual
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