77253

Heptafluorobutyric anhydride

derivatization grade (GC derivatization), LiChropur^™, ≥99.0%

• Synonyme(s) : HFBA
• Formule linéaire : (CF₃CF₂CF₂CO)₂O
• Numéro CAS: 336-59-4
• Poids moléculaire : 410.06
• UNSPSC Code: 41115716
• NACRES: NA.22
• PubChem Substance ID: 329767572
• EC Number: 206-410-8
• Beilstein/REAXYS Number: 856036
• MDL number: MFCD00000432
• Assay: ≥99.0% (GC), ≥99.0%
• Form: liquid

Propriétés

• grade: derivatization grade (GC derivatization)
• Quality Segment: 100
• assay: ≥99.0% (GC), ≥99.0%
• form: liquid
• quality: LiChropur^™
• reaction suitability: reagent type: derivatization reagent; reaction type: Acylations
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.287 (lit.)
• bp: 108-110 °C (lit.)
• mp: −43 °C (lit.)
• density: 1.674 g/mL at 20 °C
• SMILES string: FC(F)(F)C(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)C(F)(F)F
• InChI: 1S/C8F14O3/c9-3(10,5(13,14)7(17,18)19)1(23)25-2(24)4(11,12)6(15,16)8(20,21)22
• InChI key: UFFSXJKVKBQEHC-UHFFFAOYSA-N

Description

General description

Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.

Application

Learn more in the Product Information

Packaging

Clear borosilicate glass, high hydrolytic resistance (Type I)

Analysis Note

Suitable for derivatization of aldosterone, digoxin, digitoxin and metabolites, estradiol, postaglandins F_1α and F_2α, 3-oxo-Δ⁴-steroids, steroids and testosterone.

Other Notes

Reagent for 3-enol heptafluorobutyrate, heptafluorobutyrate, heptafluorobutyryl, 17-heptafluorobutyryl and 17-heptafluorobutyrate.

HFAA acylates amines, amino acids and other compounds. HFBA derivatives are highly volatile: used in GC separation

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Skin Corr. 1B
• Classe de stockage: 8A - Combustible corrosive hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter