203389
Blebbistatin, Racemic
≥97% (HPLC), liquid, Myosin II inhibitor, Calbiochem®
Synonyme(s) :
InSolutionBlebbistatin, Racemic
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About This Item
Formule empirique (notation de Hill):
C18H16N2O2
Poids moléculaire :
292.33
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Produits recommandés
product name
Blebbistatin, Racemic, InSolution, ≥97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II
Niveau de qualité
Pureté
≥97% (HPLC)
Forme
liquid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
desiccated (hygroscopic)
protect from light
Conditions d'expédition
wet ice
Température de stockage
−20°C
Description générale
A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
Actions biochimiques/physiologiques
Cell permeable: yes
Primary Target
ATPase
ATPase
Product does not compete with ATP.
Reversible: yes
Target IC50: <100 µM inhibiting the ATPase and gliding motility of human platelets
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Forme physique
A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Autres remarques
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
188.6 °F - closed cup - (Dimethylsulfoxide)
Point d'éclair (°C)
87 °C - closed cup - (Dimethylsulfoxide)
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Kevin X Lau et al.
Nature communications, 11(1), 2420-2420 (2020-05-18)
Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast stem cells, which correspond to pluripotent cells at a late post-implantation stage of embryogenesis. Heterogeneity within hPSC cultures complicates this interspecies comparison.
Martin S Weiß et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11(19), e2305947-e2305947 (2024-03-13)
Tissue homeostasis and disease states rely on the formation of new blood vessels through angiogenic sprouting, which is tightly regulated by the properties of the surrounding extracellular matrix. While physical cues, such as matrix stiffness or degradability, have evolved as
Catarina Domingues et al.
Frontiers in cell and developmental biology, 8, 678-678 (2020-09-10)
The mechanical properties of the extracellular environment are interrogated by cells and integrated through mechanotransduction. Many cellular processes depend on actomyosin-dependent contractility, which is influenced by the microenvironment's stiffness. Here, we explored the influence of substrate stiffness on the proteome
Cell segregation via differential collision modes between heterotypic cell populations.
Lucia, et al.
Molecular Biology of the Cell, 33, ar129-ar129 (2023)
Lawrence J Dooling et al.
Nature biomedical engineering, 7(9), 1081-1096 (2023-04-25)
In solid tumours, the abundance of macrophages is typically associated with a poor prognosis. However, macrophage clusters in tumour-cell nests have been associated with survival in some tumour types. Here, by using tumour organoids comprising macrophages and cancer cells opsonized
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